跳转至内容
Merck
CN
所有图片(1)

主要文件

查看所有文档

SBR00011

Sigma-Aldrich

克拉霉素，现成溶液

50 mg/mL in DMSO

别名:

6-O-甲基红霉素

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C38H69NO13
CAS号:
81103-11-9
分子量:
747.95
MDL编号:
MFCD00865140
UNSPSC代码:
51102829
PubChem化学物质编号:
329824644
NACRES:
NA.85

描述

Ready Made Solution

质量水平

200

表单

liquid

储存条件

dry media (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.)

浓度

50 mg/mL in DMSO

颜色

colorless to faint yellow

抗生素抗菌谱

Gram-positive bacteria

作用机制

protein synthesis | interferes

储存温度

−20°C

SMILES字符串

N([C@@H]1[C@H]([C@@H](O[C@@H](C1)C)O[C@@H]2[C@H]([C@@H]([C@H](C(=O)O[C@@H]([C@]([C@@H]([C@H](C(=O)[C@@H](C[C@]2(OC)C)C)C)O)(O)C)CC)C)O[C@@H]3O[C@H]([C@@H]([C@@](C3)(OC)C)O)C)C)O)(C)C

InChI

1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1

InChI key

AGOYDEPGAOXOCK-KCBOHYOISA-N

相关类别

一般描述

克拉霉素是一种大环内酯类抗生素，具有抗菌和抗炎作用。它是红霉素 A 的半合成 14 元衍生物，在酸性条件下抗降解。

应用

克拉霉素可用于-
  • 研究克拉霉素对动脉灌注兔左心室楔形制剂的 QT、Tp-e 和促心律失常事件的速率依赖性变化的影响
  • 表达 GFP（绿色荧光蛋白）的寄生虫的培养靶向顶质体，以进一步进行显微镜分析
  • NAB741 与克拉霉素在微量滴定板中的协同作用研究。

生化/生理作用

大环内酯类，如克拉霉素，通过与 50S 核糖体亚基结合，阻止细菌中的蛋白质合成。它还与其他核糖体蛋白结合，并阻止肽-dyl-tRNA 的易位。在难治性哮喘患者中，它能够调节白细胞介素 8（IL-8） 的水平，以及中性粒细胞在肺中的积聚和活化。因此，它可能被用作哮喘的附加疗法，以减少非嗜酸性气道炎症。

包装

2ML

储存及稳定性

保存于密闭容器内，置于干燥通风处。储存类别（TRGS 510）可燃液体。

其他说明

保存于密闭容器内，置于干燥通风处。储存类别（TRGS 510）：可燃液体

储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

188.6 °F

闪点(°C)

87 °C

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000268874
0000274912
0000268874
0000274912
0000126285

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Jodie L Simpson et al.
American journal of respiratory and critical care medicine, 177(2), 148-155 (2007-10-20)
Patients with refractory asthma have persistent symptoms despite maximal treatment with inhaled corticosteroids and long-acting bronchodilators. The availability of add-on therapies is limited, and effective add-on therapies that target noneosinophilic airway inflammation are needed. Macrolide antibiotics, such as clarithromycin, have
Shaobin Jia et al.
British journal of pharmacology, 164(2), 308-316 (2010-12-25)
Drug-induced torsades de pointes (TdP) often occurs during bradycardia due to reverse use-dependence. We tested the hypothesis that inhibition or enhancement of late sodium current (I(Na,L) ) could modulate the drug-induced reverse use-dependence in QT and T(p-e) (an index of
Eric H Ekland et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 25(10), 3583-3593 (2011-07-13)
Malarial parasites have evolved resistance to all previously used therapies, and recent evidence suggests emerging resistance to the first-line artemisinins. To identify antimalarials with novel mechanisms of action, we have developed a high-throughput screen targeting the apicoplast organelle of Plasmodium
Martti Vaara et al.
Antimicrobial agents and chemotherapy, 54(8), 3341-3346 (2010-05-19)
Polymyxins are cationic lipopeptides (five cationic charges) and the last resort for the treatment of serious Gram-negative infections caused by multiresistant strains. NAB741 has a cyclic peptide portion identical to that of polymyxin B but carries in the linear peptide
T Mazzei et al.
The Journal of antimicrobial chemotherapy, 31 Suppl C, 1-9 (1993-03-01)
After the discovery of erythromycin and other natural compounds, including oleandomycin, spiramycin, josamycin and midecamycin, much research has been devoted to synthesizing derivatives or analogues with improved chemical, biological and pharmacokinetic properties. These new macrolides are semisynthetic molecules that differ

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门