所有图片(1)
About This Item
经验公式（希尔记法）:
C38H69NO13
CAS号:
分子量:
747.95
MDL编号:
UNSPSC代码:
51101500
PubChem化学物质编号:
NACRES:
NA.85
描述
Ready Made Solution
质量水平
形式
liquid
储存条件
dry media (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.)
浓度
50 mg/mL in DMSO
颜色
colorless to faint yellow
抗生素抗菌谱
Gram-positive bacteria
作用机制
protein synthesis | interferes
储存温度
−20°C
InChI
1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
InChI key
AGOYDEPGAOXOCK-KCBOHYOISA-N
一般描述
克拉霉素是一种大环内酯类抗生素，具有抗菌和抗炎作用。它是红霉素 A 的半合成 14 元衍生物，在酸性条件下抗降解。
应用
克拉霉素可用于-
- 研究克拉霉素对动脉灌注兔左心室楔形制剂的 QT、Tp-e 和促心律失常事件的速率依赖性变化的影响
- 表达 GFP（绿色荧光蛋白）的寄生虫的培养靶向顶质体，以进一步进行显微镜分析
- NAB741 与克拉霉素在微量滴定板中的协同作用研究。
生化/生理作用
大环内酯类，如克拉霉素，通过与 50S 核糖体亚基结合，阻止细菌中的蛋白质合成。它还与其他核糖体蛋白结合，并阻止肽-dyl-tRNA 的易位。在难治性哮喘患者中，它能够调节白细胞介素 8（IL-8） 的水平，以及中性粒细胞在肺中的积聚和活化。因此，它可能被用作哮喘的附加疗法，以减少非嗜酸性气道炎症。
包装
2ML
储存及稳定性
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.
其他说明
保存于密闭容器内，置于干燥通风处。储存类别（TRGS 510）：可燃液体
WGK
WGK 1
闪点(°F)
188.6 °F
闪点(°C)
87 °C
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