SARS-COV-2-Spike-RBD epitope (480-499)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or (2019-nCoV) is a novel coronavirus that emerged in December 2019 and has since infected millions of people worldwide.1 The Spike protein (also known as S protein) is the most studied of the coronaviruses proteins, since it contains the Receptor-Binding-Domain (RBD) for the ligand on the host cell membrane (the ACE2 protein), and also has epitopes recognized by T and B cells.

SARS-COV-2-Spike-RBD epitope (480-499) is a synthetic peptide corresponding to the amino acid sequence of Spike RBD region (GeneID: QHD43416.1) in positions 480-499.Peptides derived from the SARS-COV-2-Spike-RBD protein can be recognized by anti-SARS-CoV-2-Spike protein antibodies.

The peptide may be used in various immunochemical techniques including Immunoblotting and Elisa.

The Spike protein (also known as S protein) is a type I trimeric glycoprotein that is presented on the virion membrane, giving it the appearance of a crown. The protein has two subunits: S1, or bulb, that contains the RBD3-10; and S2, or stalk, responsible for the fusion of the virion with the host cell membrane. The main receptor for SARS-CoV and SARS-CoV-2 on the membrane of the target cells is the Angiotensin 2 Converting Enzyme (ACE2), a metallopeptidase present on the membrane of many cells, including type-I and -II pneumocytes, small intestine enterocytes, kidney proximal tubules cells, the endothelial cells of arteries and veins, and the arterial smooth muscle, among other tissues.15-16

Supplied as a lyophilized powder.Purity: ≥95% (HPLC)

Store the product at −20 °C. After initial thawing, it is recommended to store the peptide in working aliquots at −20 °C. Recommended thawing solution: Water.

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