KD-Validated Anti SCARB2 Antibody, clone 24GB1520, Rabbit Monoclonal

The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

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A synthesized peptide corresponding to a sequence within amino acids 61-100 of human LIMPII [NP_005497.1].

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.

Solution in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.