Anti-ABCE1 Antibody, clone 1N4I7, Rabbit Monoclonal

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

A synthetic peptide corresponding to a sequence within amino acids 500-599 of human ABCE1 (P61221).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

WB, IF/ICC