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安全信息

SAB5702751

Sigma-Aldrich

Anti-FUBP1 Antibody, clone 1G6X5, Rabbit Monoclonal

别名:

FBP, FUBP, hDH V

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.46

生物来源

rabbit

质量水平

物料

colorless

克隆

1G6X5, monoclonal

表单

liquid

分子量

75 kDa

种属反应性

human, rat, rat

浓度

0.39 mg/mL

技术

immunofluorescence: 1:50 - 1:200
immunohistochemistry: 1:50 - 1:200
western blot: 1:500 - 1:2000

颜色

colorless

同位素/亚型

IgG

免疫原序列

YQQQAQPPPAAPAGAPTTTQTNGQGDQQNPAPAGQVDYTKAWEEYYKKMGQAVPAPTGAPPGGQPDYSAAWAEYYRQQAAYYAQTSPQGMPQHPPAPQGQ

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... FUBP1(8880)

一般描述

The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

免疫原

A synthetic peptide corresponding to a sequence within amino acids 545-644 of human FUBP1 (Q96AE4).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

应用

WB, IHC, IF/ICC

储存分类代码

10 - Combustible liquids

WGK

WGK 1

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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