Anti-PHOX2B Antibody, clone 4W5J8, Rabbit Monoclonal

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016]

A synthetic peptide corresponding to a sequence within amino acids 215-314 of human PHOX2B (Q99453).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

WB