SAB5702439
Anti-PFKFB3 Antibody, clone 7X10D9, Rabbit Monoclonal
别名:
IPFK2, PFK2, iPFK-2
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关于此项目
NACRES:
NA.46
UNSPSC Code:
12352203
Species reactivity:
mouse
Technique(s):
immunohistochemistry: 1:50 - 1:200, immunoprecipitation (IP): 1:50 - 1:200, western blot: 1:500 - 1:2000
Application:
IHC, IP, WB
Citations:
-
species reactivity
mouse
concentration
1 mg/mL
technique(s)
immunohistochemistry: 1:50 - 1:200, immunoprecipitation (IP): 1:50 - 1:200, western blot: 1:500 - 1:2000
color
colorless
isotype
IgG
immunogen sequence
LDKSAEEMPYLKCPLHTVLKLTPVAYGCRVESIYLNVESVCTHRERSEDAKKGPNPLMRRNSVTPLASPEPTKKPRINSFEEHVASTSAALPSCLPPEVPT
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
biological source
rabbit
conjugate
unconjugated
material
colorless
clone
7X10D9, monoclonal
form
liquid
mol wt
60 kDa
Quality Level
Gene Information
human ... PFKFB3(5209)
General description
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human PFKFB3 (NP_004557.1).
PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Application
WB, IHC, IP
signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 2 - Skin Sens. 1
存储类别
10 - Combustible liquids
wgk
WGK 3
法规信息
常规特殊物品
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