生物来源
rabbit
质量水平
物料
colorless
克隆
4J4A3, monoclonal
形式
liquid
分子量
274 kDa
种属反应性
rat, rat, human
浓度
1 mg/mL
技术
immunofluorescence: 1:50 - 1:200
western blot: 1:500 - 1:2000
颜色
colorless
同位素/亚型
IgG
免疫原序列
TTKSVKALSSLHGDDQDSEDEVLTIPEVKVHSGRGAGAESSHPVRNAQSNALQEREDDRVGLVRGEKARKGKSSSAQQKTVSSTKLVSFHDDSDEDLLHI
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... IGF2R(3482)
一般描述
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
免疫原
A synthetic peptide corresponding to a sequence within amino acids 2392-2491 of human Cation-independent M6PR (IGF2R) (P11717).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
应用
WB, IF/ICC
WGK
WGK 1
法规信息
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