Anti-SPOP Antibody, clone 2N8L8, Rabbit Monoclonal

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

A synthetic peptide corresponding to a sequence within amino acids 250-350 of human SPOP (O43791).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

WB