Anti-UBE4A Antibody, clone 2A5N2, Rabbit Monoclonal

This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn′s disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UBE4A (Q14139).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

WB