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主要文件

安全信息

SAB5701665

Sigma-Aldrich

Anti-FEN-1 antibody produced in rabbit

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.43

生物来源

rabbit

质量水平

抗体产品类型

primary antibodies

克隆

monoclonal

表单

liquid

种属反应性

human, mouse, rat

浓度

0.23 mg/mL

技术

immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... FEN1(2237)

一般描述

The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]

免疫原

A synthesized peptide derived from human FEN-1

外形

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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