Monoclonal Anti-DLL4 purified low endotoxin produced in mouse

DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach.

The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.

recombinant soluble human DLL4

Phosphate buffered saline (PBS), pH 7.4

Purified by protein-A affinity chromatography.

Store at 2-8°C. Do not freeze.

The antibody solution should be gently mixed before use.