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Merck
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安全信息

SAB4702056

Monoclonal Anti-CD63 PerCP produced in mouse

new

别名:

Granulophysin, LAMP-3, ME491, MLA1, OMA81H, TSPAN30, Tetraspanin-30, Tspan-30

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About This Item

UNSPSC代码:
12352203

偶联物

Peridinin-Chlorophyll-Protein Complex conjugate

质量水平

抗体产品类型

primary antibodies

克隆

MEM-259, monoclonal

表单

buffered aqueous solution

种属反应性

human

技术

flow cytometry: suitable

同位素/亚型

IgG1

UniProt登记号

储存温度

2-8°C

靶向翻译后修饰

unmodified

基因信息

human ... CD63(967)

一般描述

CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. It is also present in the plasma membrane, usually following cell activation. Hence, it has become an widely used basophil activation marker. In mast cells, however, CD63 exposition does not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas.

特异性

The antibody MEM-259 reacts with an extracellular/luminal epitope of CD63 (LAMP-3), a 40-60 kDa tetraspan glycoprotein expressed by granulocytes, platelets, T cells, monocytes/macrophages and endothelial cells. Cell surface exposition of CD63 is usually activation-dependent.

免疫原

HPB-ALL T cell line

外形

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

制备说明

Purified antibody is conjugated with activated Peridinin-Chlorophyll Protein (PerCP) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

储存及稳定性

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

其他说明

The antibody solution should be gently mixed before use.

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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历史批次信息供参考:

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