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此商品 | OGS621 | OGS620 | OGS619 |
|---|---|---|---|
| peptide cleavage EKT | peptide cleavage EKT | peptide cleavage EKT | peptide cleavage EKT |
| origin of replication pUC | origin of replication pUC | origin of replication pUC | origin of replication pUC |
| peptide tag location N-terminal | peptide tag location N-terminal | peptide tag location N-terminal | peptide tag location C-terminal |
| bacteria selection ampicillin | bacteria selection ampicillin | bacteria selection ampicillin | bacteria selection ampicillin |
| mol wt size 5913 bp | mol wt size 4610 bp | mol wt size 4568 bp | mol wt size 4530 bp |
一般描述
Heat Shock Proteins 70 (HSP70), also known as HSPA1A (heat shock protein family A (Hsp70) member 1A) or HSPA1B (heat shock protein family A (Hsp70) member 1B) is encoded by the gene mapped to human chromosome 6p21.3. xHSP70 is a highly conserved protein family with four members such as the constitutive (or cognate) HSP73, the stress-inducible HSP72, the glucose regulated proteins (grp)78 and grp75. During heat shock, HSP70s concentrate in the cell nuclei and return to the cytoplasm when the shock is removed.
免疫原
Synthetic peptide from the internal region of human HSP70 protein, conjugated to KLH
应用
The antibody has been used in various immunochemical techniques including immunoblotting (∼70 kDa) and immunoprecipitation.Detection of the HSP70 band by Immunoblotting is specifically inhibited by the immunogen.
生化/生理作用
Heat Shock Proteins 70 (HSP70) plays a key role in stress response, including heat stress, in every organism in which the proteins have been examined. These proteins also facilitates a wide range of folding processes, including the folding and assembly of newly synthesized proteins, refolding of misfolded and aggregated proteins, membrane translocation of organellar and secretory proteins, and control of the activity of regulatory proteins. In addition, HSP70 also play a cytoprotective role in neurodegenerative diseases such as Alzheimer′s, Parkinson′s, Huntington′s, ALS and others. Unregulated expression of HSP70s leads to the development of several types of cancer, such as malignant melanoma and renal cell cancer.
外形
Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.
其他说明
This product is for R&D use only, not for drug, household, or other uses.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Georgios D Lianos et al.
Cancer letters, 360(2), 114-118 (2015-02-28)
Heat shock proteins (HSPs) are an evolutionary family of proteins that act as molecular chaperones. According to their size they have been classified into the following families; HSP90, HSP70, HSP60, HSP40 and HSP27. They prevent the formation of nonspecific protein
M Tavaria et al.
Cell stress & chaperones, 1(1), 23-28 (1996-04-01)
The human Hsp70 family encompasses at least 11 genes which encode a group of highly related proteins. These proteins include both cognate and highly inducible members, at least some of which act as molecular chaperones. The location of cognate Hsp70s
Heat shock protein 70 in Alzheimer?s disease
Lu RC, et al.
BioMed Research International, 2014(21) (2014)
Hsp70 dynamics in vivo: effect of heat shock and protein aggregation
Zeng X, et al.
Journal of Cell Science, 117(21), 4991-5000 (2004)
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