SAB4200749
Anti-Collagen Type III (COL3A1) Antibody
mouse monoclonal, FH-7A
别名:
Anti-COL3A1, Anti-Collagen alpha-1(III) chain
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
Clone:
FH-7A, monoclonal
Species reactivity:
rat, human
Application:
ELISA
immunoblotting
immunofluorescence
immunohistochemistry
immunoblotting
immunofluorescence
immunohistochemistry
Technique(s):
ELISA: suitable
immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded rat skin sections.
immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded rat skin sections.
Citations:
7
Uniprot accession no.:
产品名称
Anti-Collagen Type III antibody, Mouse monoclonal, clone FH-7A, purified from hybridoma cell culture
biological source
mouse
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
FH-7A, monoclonal
form
buffered aqueous solution
mol wt
~70 kDa
species reactivity
rat, human
concentration
~1.0 mg/mL
technique(s)
ELISA: suitable
immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded rat skin sections.
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... COL3A1(1281)
Biochem/physiol Actions
Collagen a-1(III) (COL3A1) serves as a potent adjunct marker for both differentiating fibroadenoma (FA) from phyllodes tumor (PT) and measuring malignant potential in PTs. Overexpression of the gene in glomerular leads to the development of collagen type III glomerulopathy. Mutations in the gene is associated with the development of familial aortic aneurysms and Ehlers-Danlos syndrome.
General description
Anti-collagen type III antibody, mouse monoclonal (mouse IgG1 isotype) is derived from the FH-7A hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c immunized mouse.
Monoclonal anti-collagen type III specifically recognizes native and denatured collagen type III from human 1 and rat 2 origin. It does not recognize collagen types I, II, IV, V, VI and X.
Collagen type III, also known as collagen α-1(III) (COL3A1), is encoded by the gene mapped to human chromosome 2q24.3-q31. It is the highly expressed collagen in blood vessels and hollow organs.
Monoclonal anti-collagen type III specifically recognizes native and denatured collagen type III from human 1 and rat 2 origin. It does not recognize collagen types I, II, IV, V, VI and X.
Collagen type III, also known as collagen α-1(III) (COL3A1), is encoded by the gene mapped to human chromosome 2q24.3-q31. It is the highly expressed collagen in blood vessels and hollow organs.
Immunogen
Human Collagen Type III
Other Notes
In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
Store at -20°C. For continuous use, store at 2-8°C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
A Mutation in the Gene for Type Ill Procollagen (COL3A1)
in a Family with Aortic Aneurysms
in a Family with Aortic Aneurysms
Kontusaari S, et al.
The Journal of Clinical Investigation, 86, 1465-1473 (1990)
Collagen type III a1 as a useful diagnostic immunohistochemical marker for fibroepithelial lesions of the breast.
Wang Y, et al.
Human Pathology, 57, 176-181 (2016)
Linkage mapping of the gene for type III collagen (COL3A1) to human chromosome 2q using a VNTR polymorphism.
Tiller GE, et al.
Genomics, 20, 275-277 (1994)
Transcriptome analysis of skin fibroblasts with dominant negative COL3A1 mutations provides molecular insights into the etiopathology of vascular Ehlers-Danlos syndrome.
Chiarelli N, et al.
PLoS ONE, 13 (2018)
Glomerular Collagen V Codeposition and Hepatic Perisinusoidal Collagen III Accumulation in Canine Collagen Type III Glomerulopathy.
R?rtveit R, et al.
Veterinary Pathology, 52, 1134-1141 (2015)
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