跳转至内容
Merck
CN

SAB4200730

Anti-Connexin 43 Antibody

mouse monoclonal, CXN-6

别名:

Anti-AVSD3, Anti-CMDR, Anti-CX43, Anti-EKVP, Anti-EKVP3, Anti-GJAL, Anti-HLHS1, Anti-HSS, Anti-ODDD, Anti-PPKCA

登录 查看组织和合同定价。

选择尺寸

关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
Clone:
CXN-6, monoclonal
Species reactivity:
chicken, rat, feline, bovine, human, porcine, mouse
Application:
IF, IHC
Citations:
9

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

Anti-Connexin 43 antibody, Mouse monoclonal, clone CXN-6, hybridoma cell culture supernatant

biological source

mouse

antibody form

culture supernatant

antibody product type

primary antibodies

clone

CXN-6, monoclonal

form

buffered aqueous solution

species reactivity

chicken, rat, feline, bovine, human, porcine, mouse

packaging

antibody small pack of 25 μL

concentration

~1.0 mg/mL

technique(s)

immunoblotting: 1:5,000-1:7,500 using mouse myoblast C2C12 cell line extract, immunofluorescence: 1:500-1:1,000 using mouse myoblast C2C12 cell line, immunohistochemistry: 1:200-1:500 using heat-retrieved formalin-fixed, paraffin-embedded mouse heart sections

isotype

IgM

UniProt accession no.

P17302

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

bovine ... Gja1(281193)
cat ... Gja1(101100211)
chicken ... Gja1(395278)
human ... GJA1(2697)
mouse ... Gja1(14609)
rat ... Gja1(24392)

正在寻找类似产品? 访问 产品对比指南

General description

Connexin 43 (Cx43) is also known as gap junction alpha-1 protein (GJA1). It is mapped to human chromosome 6q22.31. Cx43 is membrane protein with four transmembrane spanning regions, which comprise the gap junction channel. The loop connecting the transmembrane regions play a key role in channel docking. The N- and C-terminal amino acids are exposed to cytoplasm.

Immunogen

synthetic peptide from the C-terminal region of Connexin 43 protein, conjugated to KLH

Biochem/physiol Actions

Connexin 43 (Cx43) function is controlled by phosphorylation, SUMOylation and ubiquitination. The C-terminal tail of Cx43 modulates cytoskeletal dynamics and cell migration properties. Mutation in Cx43 leads to dysfunction of channel regulation domain and is associated with pathogenesis of hypoplastic left heart syndrome (HLHS). Cx43 dysregulation in testis contributes to infertility and testicular tumor. A gene mutation in the Cx43 results in abnormal development of eyes and teeth in oculodentodigital dysplasia (ODDD) , craniometaphyseal dysplasia and sudden infant death syndrome. Mutations in the GJA1 results in abnormal facial and skull development in hallermann-streiff syndrome (HSS). Missense mutations in GJA1 gene is also implicated in skin disorder called the, erythrokeratodermia variabilis et progressiva (EKVP)

Physical form

The product is supplied as a culture supernatant solution containing 15 mM sodium azide as a preservative. The product contains bovine serum albumin and a human-derived protein.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

未找到合适的产品？  

试试我们的产品选型工具.

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

高风险级别生物产品--人源产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000267457
0000089485
0000267457
0000089485
079M4854V

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Connexin 43 a check-point component of cell proliferation implicated in a wide range of human testis diseases
Chevallier D, et al.
Cellular and Molecular Life Sciences, 70(7), 1207-1220 (2013)
Syndromic and non-syndromic disease-linked Cx43 mutations
Laird DW
Febs Letters, 588(8), 1339-1348 (2014)
Yan Zeng et al.
Cell & bioscience, 12(1), 191-191 (2022-12-03)
Mechanical loading promotes bone formation and osteocytes are a major mechanosensory cell in the bone. Both Piezo1 channels and connexin 43 hemichannels (Cx43 HCs) in osteocytes are important players in mechanotransduction and anabolic function by mechanical loading. However, the mechanism
Structural organization of gap junction channels
Sosinsky GE and Nicholson BJ
Biochimica et Biophysica Acta - Biomembranes, 1711(2), 99-125 (2005)
Identification of connexin43 (alpha1) gap junction gene mutations in patients with hypoplastic left heart syndrome by denaturing gradient gel electrophoresis (DGGE)
Dasgupta C, et al.
Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis, 479(1), 173-186 (2001)
查看所有相关文献

相关内容

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持