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生物来源
mouse
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
CHGA(419), monoclonal
形式
buffered aqueous solution
分子量
~50 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
immunoblotting: 10-20 μg/mL using human embryonic kidney 293T cell extract
immunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded Human Stomach sections
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CHGA(1113)
一般描述
Anti-Chromogranin-A antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the CHGA(419) hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with synthetic peptide corresponding to the C-terminal region of human Chromogranin-A protein, conjugated to KLH. Chromogranin-A protein, also known as CgA, pituitary secretory protein I (SP-1) is the major member of the granin family of acidic secretory glycoproteins that are expressed in all endocrine and neuroendocrine cells. The protein is in neuroendocrine cells distributed throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets and the secretory vesicles of neurons.
免疫原
synthetic peptide corresponding to the C-terminal region of human Chromogranin-A protein conjugated to KLH
应用
Anti-Chromogranin-A antibody has been used in immunohistochemistry,immunoblotting.
生化/生理作用
Chromogranin-A has a crucial intracellular role in secretory granule biogenesis and calcium homeostasis. Tissue-specific and context-specific proteolytic cleavage of Chromogranin-A yields polypeptides with paracrine and endocrine activity including: vasostatin, catestatin, GE25 and WE-14. Increased blood levels of Chromogranin-A have been shown in numerous inflammatory and non-inflammatory conditions, including neuroendocrine tumours (carcinoid tumors, phenochromocytomas, paragangliomas and others), renal failure, arterial hypertension, chronic heart failure and rheumatoid arthritis.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
The endocrine role for chromogranin A: a prohormone for peptides with regulatory properties
Cellular and Molecular Life Sciences, 64(22), 2863-2886 (2007)
Chromogranin A: its clinical value as marker of neuroendocrine tumours.
European Journal of Clinical Investigation, 28(6), 431-440 (1998)
Chromogranin-A production and fragmentation in patients with Takayasu arteritis
Arthritis Research & Therapy, 18(1), 187-187 (2016)
A new human chromogranin A (CgA) immunoradiometric assay involving monoclonal antibodies raised against the unprocessed central domain (145-245)
British Journal of Cancer, 79(1), 65-65 (1999)
Cell reports, 25(12), 3530-3542 (2018-12-20)
A comprehensive cellular anatomy of normal human prostate is essential for solving the cellular origins of benign prostatic hyperplasia and prostate cancer. The tools used to analyze the contribution of individual cell types are not robust. We provide a cellular
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