SAB4200725
抗-剪切因子SC-35抗体，小鼠单克隆
clone SC-35, purified from hybridoma cell culture
别名:
抗-PR264, 抗-SFRS2, 抗-SFRS2A, 抗-SRp30b, 抗-丝氨酸精氨酸二肽富含性剪切因子2(SRSF2), 抗-剪切因子35(SC35)
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关于此项目
NACRES:
NA.43
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
SC-35, monoclonal
Application:
ELISA
dot blot
immunoblotting
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
dot blot
immunoblotting
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
Species reactivity:
human, mouse, quail, hamster, frog, porcine, rat
Citations:
4
Technique(s):
ELISA: suitable
dot blot: suitable
immunoblotting: suitable
immunofluorescence: 0.125-0.25 μg/mL using HeLa cells
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
dot blot: suitable
immunoblotting: suitable
immunofluorescence: 0.125-0.25 μg/mL using HeLa cells
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
Uniprot accession no.:
产品名称
抗-剪切因子SC-35抗体，小鼠单克隆, clone SC-35, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
SC-35, monoclonal
form
buffered aqueous solution
mol wt
~35 kDa
species reactivity
human, mouse, quail, hamster, frog, porcine, rat
concentration
~1.0 mg/mL
technique(s)
ELISA: suitable
dot blot: suitable
immunoblotting: suitable
immunofluorescence: 0.125-0.25 μg/mL using HeLa cells
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SRSF2(6427)
Application
抗-剪接因子SC-35抗体已用于
- 斑点印迹
- 酶联免疫吸附测定(ELISA)
- 免疫荧光
- 免疫组织化学
- 免疫印迹
- 免疫沉淀
Biochem/physiol Actions
剪接因子SC35是pre-mRNA组成性和选择性剪接的重要调控因子。它控制基因毒性应激下的细胞凋亡。丝氨酸/精氨酸蛋白激酶1(SRPK1)可特异性磷酸化SC-35，导致p53抑制和周期蛋白D1上调。SC-35浓度升高与肺鳞状细胞癌和肺腺癌等多种癌症的侵袭性表型有关。SC35在人乳头瘤病毒(HPV)感染细胞的肿瘤进展中起致癌作用。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
General description
小鼠抗-剪接因子SC-35单克隆抗体（小鼠IgG1同种型）来源于小鼠骨髓瘤细胞与部分纯化剪接体免疫的RBF-DHJ小鼠脾细胞融合产生的SC-35杂交瘤。剪接因子SC-35，也称为丝氨酸精氨酸二肽富含性剪切因子2(SRSF2)，属于丝氨酸精氨酸二肽富含性(SR)蛋白家族。
Immunogen
HeLa细胞制备的部分纯化剪接体
Physical form
溶于0.01 M磷酸盐缓冲液（pH 7.4）中，含有15 mM叠氮化钠。
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35
Merdzhanova L, et al.
Cell Death and Differentiation, 15(12), 1815-1815 (2008)
Masashi Ueda et al.
Molecular brain, 13(1), 80-80 (2020-05-26)
Zhu-Tokita-Takenouchi-Kim (ZTTK) syndrome, a rare congenital anomaly syndrome characterized by intellectual disability, brain malformation, facial dysmorphism, musculoskeletal abnormalities, and some visceral malformations is caused by de novo heterozygous mutations of the SON gene. The nuclear protein SON is involved in
Carlos Rivera et al.
Epigenetics & chromatin, 14(1), 51-51 (2021-11-26)
Nuclear processes such as transcription and RNA maturation can be impacted by subnuclear compartmentalization in condensates and nuclear bodies. Here, we characterize the nature of nuclear granules formed by REST corepressor 2 (RCOR2), a nuclear protein essential for pluripotency maintenance
Shengyan Gao et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(25), e2206046119-e2206046119 (2022-06-16)
Nuclear speckles are non-membrane-bound organelles known as storage sites for messenger RNA (mRNA) processing and splicing factors. More recently, nuclear speckles have also been implicated in splicing and export of a subset of mRNAs, including the influenza virus M mRNA
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