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Merck
CN

SAB4200721

抗-GABA抗体，小鼠单克隆

clone GB-69, purified from hybridoma cell culture

别名:

Mouse Anti-Gamma-aminobutyric acid

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
GB-69, monoclonal
Species reactivity:
rat, monkey, frog, mouse, human, gerbil
Application:
ELISA
dot blot
immunofluorescence
immunohistochemistry
Technique(s):
ELISA: suitable
dot blot: suitable
immunofluorescence: 5-10 μg/mL using human pancreatic tumor AsPC1 cell line
immunohistochemistry: 1-2.5 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human brain and/or cerebellum sections
Citations:
4

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产品名称

抗-GABA抗体，小鼠单克隆, clone GB-69, purified from hybridoma cell culture

biological source

mouse

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

GB-69, monoclonal

form

buffered aqueous solution

species reactivity

rat, monkey, frog, mouse, human, gerbil

concentration

~1.0 mg/mL

technique(s)

ELISA: suitable
dot blot: suitable
immunofluorescence: 5-10 μg/mL using human pancreatic tumor AsPC1 cell line
immunohistochemistry: 1-2.5 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human brain and/or cerebellum sections

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... GABRA1(2554)
mouse ... Gabra1(14394)
rat ... Gabra1(29705)
rhesus monkey ... Gabra1(574302)

相关类别

Application

小鼠单克隆抗GABA抗体已被用于：
  • 免疫荧光
  • 免疫组织化学
  • 酶链免疫吸附检测 (ELISA)
  • 斑点印迹

Biochem/physiol Actions

γ-氨基丁酸（GABA）是主要的抑制性神经递质。GABA介导快速的中枢神经系统突触抑制，并作为感觉回路在功能发育中起关键作用。GABA促进免疫细胞、胚胎干细胞和皮质祖细胞的增生。此外，它还涉及蛋白质合成和代谢，并在肌肉张力、血压、心率和呼吸的调节中起重要作用。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。

General description

小鼠单克隆抗GABA抗体（小鼠IgG1同种型）来源于小鼠骨髓瘤细胞与纯化BSA偶联GABA免疫的小鼠脾细胞融合产生的GB-69 杂交瘤。γ-氨基丁酸（GABA）存在于脊椎动物的中枢神经系统（CNS）中。谷氨酸脱羧酶（GAD）催化L-谷氨酸的酶促脱羧反应，形成GABA。

Immunogen

与BSA偶联的纯化的GABA

Physical form

0.01 M 磷酸盐缓冲液 (pH 7.4) 中的溶液，含 15 mM 叠氮化钠

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000444884
0000444884
0000395427
0000395427
0000342526

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Distribution of glycine immunoreactivity in the brain of the Siberian sturgeon (Acipenser baeri): Comparison with gamma-aminobutyric acid
Adrio F, et al.
The Journal of Comparative Neurology, 519(6), 1115-1142 (2011)
GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium
Ring H, et al.
PLoS ONE, 7(5), e36874-e36874 (2012)
Kunihiko Obata
Proceedings of the Japan Academy. Series B, Physical and biological sciences, 89(4), 139-156 (2013-04-12)
Signal transmission through synapses connecting two neurons is mediated by release of neurotransmitter from the presynaptic axon terminals and activation of its receptor at the postsynaptic neurons. γ-Aminobutyric acid (GABA), non-protein amino acid formed by decarboxylation of glutamic acid, is
Wei Fan et al.
eLife, 10 (2021-05-28)
Sphingolipids are important structural components of cell membranes and prominent signaling molecules controlling cell growth, differentiation, and apoptosis. Sphingolipids are particularly abundant in the brain, and defects in sphingolipid degradation are associated with several human neurodegenerative diseases. However, molecular mechanisms

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