抗体形式
purified from hybridoma cell culture
质量水平
抗体产品类型
primary antibodies
克隆
DE-U-10, monoclonal
形式
buffered aqueous solution
分子量
antigen ~55 kDa
种属反应性
rat, rabbit, hamster, porcine, goat, bovine, chicken, toad, sheep, mouse, human
增强验证
independent
Learn more about Antibody Enhanced Validation
浓度
~1.0 mg/mL
技术
immunoblotting: 0.5-1 μg/mL using whole extract of mouse myoblast C2C12 cells
immunofluorescence: 2-5 μg/mL using mouse myoblast C2C12 cells
immunohistochemistry: 2.5-5 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded Human Appendix
microarray: suitable
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... DES(1674)
mouse ... Des(13346)
rat ... Des(64362)
相关类别
一般描述
Anti-Desmin antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma DE-U-10 produced by the fusion of mouse myeloma cells and splenocytes from an immunized BALB/C mouse. Desmin, a major intermediate filament protein in skeletal, cardiac and smooth muscle cells. It is predominantly localised to filamentous extrasarcomeric cytoskeleton, which links neighbouring myofibrils and connects the myofibrillar apparatus with the subsarcolemmal cytoskeleton, myonuclei and mitochondria.
免疫原
Desmin purified from pig stomach
应用
Anti-Desmin antibody, Mouse monoclonal has been used in:
- immunoblotting
- immunofluorescence
- immunohistochemistry
- microarray
生化/生理作用
Mutations is the desmin gene (known as desminopathy or DRM) are associated with several human diseases such as atrophy and facial muscle weakness, cardiomyopathy, cardiac arrhythmias and restrictive heart failure and are characterized by intracellular desmin aggregates. Anti-Desmin antibodies can be implemented for cancer research and diagnostics since elevated levels of desmin characterize several types of muscle tissue tumors, such as leiomyomas and rhabdomyosarcomas. The antibody may also be used for meat research measurements.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Harald Bär et al.
Journal of structural biology, 148(2), 137-152 (2004-10-13)
Desmin, the major intermediate filament (IF) protein of muscle, is evolutionarily highly conserved from shark to man. Recently, an increasing number of mutations of the desmin gene has been described to be associated with human diseases such as certain skeletal
Chuan Xu et al.
PNAS nexus, 2(11), pgad350-pgad350 (2023-11-13)
Interferon ɛ (IFNɛ) is a unique type I IFN that has been implicated in host defense against sexually transmitted infections. Zika virus (ZIKV), an emerging pathogen, can infect the female reproductive tract (FRT) and cause devastating diseases, particularly in pregnant
Yuan H Brad Kim et al.
Meat science, 95(2), 412-418 (2013-06-12)
Forty eight lamb carcasses with temperature and pH monitored were obtained from two commercial plants. At 24h post mortem both loins (M. longissimus) from each carcass were randomly allocated to a) unaged frozen at -18°C, (b) aged at -1.5°C for
Tumor markers: An overview
Babu GS, et al.
Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie, 4(2), 87-87 (2012)
The physiological role of cardiac cytoskeleton and its alterations in heart failure
Sequeira V, et al.
Biochimica et Biophysica Acta - Biomembranes, 1838(2), 700-722 (2014)
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