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生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
K79bB10, monoclonal
形式
buffered aqueous solution
种属反应性
cat, rabbit, mouse, guinea pig, rat, dog, porcine, zebrafish, human
包装
antibody small pack of 25 μL
浓度
~1 mg/mL
技术
immunohistochemistry: 5-10 μg/mL using heat−retrieved formalin-fixed, paraffin-embedded Rat pancreas sections and Biotin/ExtrAvidin®-Peroxidase staining system.
radioimmunoassay: suitable
同位素/亚型
IgG1
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
cat ... Gcg(101097825)
dog ... Gcg(403571)
guinea pig ... Gcg(100135526)
human ... GCG(2641)
mouse ... Gcg(14526)
pig ... Gcg(397595)
rabbit ... Gcg(100341777)
rat ... Gcg(24952)
一般描述
Glucagon is a hormone peptide produced in Langerhans islets α-cells in the pancreas. The active form of glucagon is derived from the cleavage of preproglucagon (GCG). Additional cleavage peptides are oxyntomodulin and glucagon-like peptide-1 (GLP1).
免疫原
Polymerized porcine glucagon
应用
Monoclonal Anti-Glucagon antibody produced in mouse has been used in immunofluorescence staining. The product may be used in several immunochemical techniques including immunohistochemistry and radioimmunoassay (RIA).
生化/生理作用
The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis and ketogenesis. Glucagon has an antagonistic effect in the maintenance of normoglycemia to those of insulin and is suppressed by GLP1. Thus up-regulation of glucagon is leading to increased blood glucose levels. Glucagon-specific antibodies would prove useful as a Langerhans islets α cell, glucagonomas and tumor markers applying immunohistochemical techniques, and as an analytical tool in quantification of the hormone.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
法律信息
ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
法规信息
常规特殊物品
Pancreatic regulation of glucose homeostasis
Roder PV, et al.
Experimental & Molecular Medicine, 48(3), e219-e219 (2016)
Metabolic regulation of GLP-1 and PC1/3 in pancreatic
Sancho V, et al.
Testing, 12 (2017)
The role of glucagon on type 2 diabetes at a glance
Godoy-Matos AF, et al.
Diabetology & Metabolic Syndrome, 6 (2014)
Qingsheng Liu et al.
Advanced materials (Deerfield Beach, Fla.), 33(39), e2102852-e2102852 (2021-08-08)
Encapsulation of insulin-producing cells is a promising strategy for treatment of type 1 diabetes. However, engineering an encapsulation device that is both safe (i.e., no cell escape and no breakage) and functional (i.e., low foreign-body response (FBR) and high mass
Sara Ibrahim et al.
Disease models & mechanisms, 13(6) (2020-05-28)
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