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安全信息

SAB4200685

Sigma-Aldrich

Anti-Glucagon antibody, Mouse monoclonal

clone K79bB10, purified from hybridoma cell culture

别名:

Monoclonal Anti-Glucagon antibody produced in mouse, GCG, GLP1, GLP2, GRPP

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About This Item

UNSPSC代码:
51111800
NACRES:
NA.41

生物来源

mouse

质量水平

200

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

K79bB10, monoclonal

表单

buffered aqueous solution

种属反应性

cat, rabbit, mouse, guinea pig, rat, dog, porcine, zebrafish, human

包装

antibody small pack of 25 μL

浓度

~1 mg/mL

技术

immunohistochemistry: 5-10 μg/mL using heat−retrieved formalin-fixed, paraffin-embedded Rat pancreas sections and Biotin/ExtrAvidin®-Peroxidase staining system.
radioimmunoassay: suitable

同位素/亚型

IgG1

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

cat ... Gcg(101097825)
dog ... Gcg(403571)
guinea pig ... Gcg(100135526)
human ... GCG(2641)
mouse ... Gcg(14526)
pig ... Gcg(397595)
rabbit ... Gcg(100341777)
rat ... Gcg(24952)

一般描述

Glucagon is a hormone peptide produced in Langerhans islets α-cells in the pancreas. The active form of glucagon is derived from the cleavage of preproglucagon (GCG). Additional cleavage peptides are oxyntomodulin and glucagon-like peptide-1 (GLP1).

免疫原

Polymerized porcine glucagon

应用

Monoclonal Anti-Glucagon antibody produced in mouse has been used in immunofluorescence staining. The product may be used in several immunochemical techniques including immunohistochemistry and radioimmunoassay (RIA).

生化/生理作用

The biological activities of pancreatic glucagon include glycogenolysis, lipolysis, gluconeogenesis and ketogenesis. Glucagon has an antagonistic effect in the maintenance of normoglycemia to those of insulin and is suppressed by GLP1. Thus up-regulation of glucagon is leading to increased blood glucose levels. Glucagon-specific antibodies would prove useful as a Langerhans islets α cell, glucagonomas and tumor markers applying immunohistochemical techniques, and as an analytical tool in quantification of the hormone.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

法律信息

ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
22180406
0000317678
0000317683
22180406
0000317683

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The role of glucagon on type 2 diabetes at a glance
Godoy-Matos AF, et al.
Diabetology & Metabolic Syndrome, 6 (2014)
Qingsheng Liu et al.
Advanced materials (Deerfield Beach, Fla.), 33(39), e2102852-e2102852 (2021-08-08)
Encapsulation of insulin-producing cells is a promising strategy for treatment of type 1 diabetes. However, engineering an encapsulation device that is both safe (i.e., no cell escape and no breakage) and functional (i.e., low foreign-body response (FBR) and high mass
Metabolic regulation of GLP-1 and PC1/3 in pancreatic
Sancho V, et al.
Testing, 12 (2017)
Abhishek A Kulkarni et al.
Oxidative medicine and cellular longevity, 2018, 1324739-1324739 (2018-05-23)
It is well known that a chronic state of elevated reactive oxygen species (ROS) in pancreatic β-cells impairs their ability to release insulin in response to elevated plasma glucose. Moreover, at its extreme, unmitigated ROS drives regulated cell death. This
An In Vivo Zebrafish Model for Interrogating ROS-Mediated Pancreatic
Kulkarni AA, et al.
Oxidative Medicine and Cellular Longevity, 2018 (2018)
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