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SAB4200679

Sigma-Aldrich

Monoclonal Anti-Actin, α-Smooth Muscle - Peroxidase antibody produced in mouse

clone 1A4, purified from hybridoma cell culture

别名:

AAT6, ACTSA, MYMY5, actin, alpha 2, aorta, smooth muscle

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25 μG
¥1,455.13

¥1,455.13


预计发货时间2025年3月04日详情

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25 μG
¥1,455.13

About This Item

UNSPSC代码:
51111800
NACRES:
NA.41

¥1,455.13


预计发货时间2025年3月04日详情

针对您的靶标提供了无防腐剂重组抗体。试用 ZRB05665

获取大包装报价

生物来源

mouse

质量水平

偶联物

peroxidase conjugate

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

1A4, monoclonal

表单

lyophilized powder

分子量

antigen ~42 kDa

种属反应性

frog, mouse, hamster, chicken, viper, bovine, crayfish, goat, rat, cat, sheep, guinea pig, lizard, human, rabbit, dog, snail

技术

direct ELISA: suitable
immunoblotting: 2-4 μg/mL using extracts of mouse heart tissues
immunohistochemistry: 5-10 μg/mL using human appendix or tonsil tissue sections

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此商品
45018962393L4158
assay

98%

assay

99.999% trace metals basis

assay

≥99.0% (anhydrous)

assay

-

mp

53-56 °C (lit.)

mp

53-56 °C (lit.)

mp

53-56 °C (lit.)

mp

53-56 °C (lit.)

一般描述

Monoclonal Anti-Actin, α-Smooth Muscle-HRP (mouse IgG2a isotype) is derived from the hybridoma 1A4 produced by the fusion of mouse myeloma cells and splenocytes from mice immunized with a synthetic peptide corresponding to a sequence of α-smooth muscle actin, conjugated to KLH. Actin is a highly conserved protein, expressed as six isoforms and represents differentiation markers of muscle tissues.

免疫原

a synthetic peptide corresponding to a sequence at the NH2 terminal synthetic decapeptide of α-smooth muscle actin, conjugated to KLH.

应用

Monoclonal Anti-Actin, α-Smooth Muscle - Peroxidase antibody has been used in:
  • direct-immunoblotting
  • direct-immunohistochemistry
  • direct- enzyme linked immunosorbent assay (ELISA)
  • direct staining of tissues and cells
  • characterization of stromal cell heterogeneity in various organs and distinguish smooth muscle cells from fibroblasts in mixed cultures.

生化/生理作用

Actin and Myosin are two major cytoskeletal proteins implicated in cell motility, both constitutively expressed in many cells types and are involved in a myriad of cellular processes including locomotion, secretion, cytoplasmic streaming, phagocytosis and cytokinesis. It has been shown that relative proportions of actin isoforms are diverse in smooth muscles of different organs and change within the same population of smooth muscle cells during development, pathological situations and different culture conditions.

外形

Supplied as lyophilized powder. After reconstitution with 0.1 mL of distilled water to a final antibody concentration of ∼ 2 mg/mL, the solution contains 1% BSA, 2.5% trehalose, 0.05% MIT in 0.01 M sodium phosphate buffered saline

制备说明

Reconstitute in 0.1mL of distilled water.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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象形图

Health hazard

警示用语:

Danger

危险分类

Aquatic Chronic 3 - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品
含少量动物源组分生物产品
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    A monoclonal antibody against alpha-smooth muscle actin: a new probe for smooth muscle differentiation.
    Skalli O, et al.
    The Journal of Cell Biology, 103(6), 2787-2796 (1986)
    Ayelén M Santamans et al.
    Science advances, 10(3), eadk6524-eadk6524 (2024-01-19)
    Pulmonary hypertension (PH) can affect both pulmonary arterial tree and cardiac function, often leading to right heart failure and death. Despite the urgency, the lack of understanding has limited the development of effective cardiac therapeutic strategies. Our research reveals that

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