生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
CAD-5, monoclonal
表单
buffered aqueous solution
种属反应性
human
浓度
~1 mg/mL
技术
immunoblotting: 5-10 μg/mL using whole extract of human HeLa cells.
immunohistochemistry: 5-10 μg/mL using Biotin/ExtrAvidin®-Peroxidase staining system of heat-retrieved formalin-fixed, paraffin-embedded human heart sections
immunoprecipitation (IP): 5-10 μg/mL using whole extract of human HeLa cells.
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CDH13(1012)
一般描述
Monoclonal Anti-CDH13 (mouse IgG1 isotype) is derived from the hybridoma CAD-5 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. Cadherin 13 (CDH13) is a member of the cadherins multigene family of single-chain glycoprotein receptors. It is a glycosylphosphatidylinositol (GPI)- anchored member and a low-density lipoprotein (LDL)-binding protein usually found in smooth muscle. CDH13 is present in the brain and cardiovascular system. It is mapped on the human chromosome at 16q23.3.
特异性
Monoclonal Anti-CDH13 recognizes human Cadherin 13.
免疫原
N-terminal His-tagged recombinant protein of human Cadherin 13
应用
Monoclonal Anti-CDH13 antibody produced in mouse may be used in:
- immunoblotting
- immunoprecipitation
- immunohistochemistry
生化/生理作用
Cadherin (CDH) is involved in mediating Ca2+-dependent cell-cell adhesion. Abnormalities in the CDH13 gene have been identified in human malignancies. Promoter methylation of CDH13 results in gene silencing in non-small cell lung carcinoma (NSCLC). CDH13 is involved in cell migration, axon guidance and neurite growth. It is also associated with attention-deficit/hyperactivity disorder (ADHD). CDH13 is also involved in autism spectrum disorders, bipolar disorder, schizophrenia and depression.
外形
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide
储存及稳定性
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
法律信息
ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition
Rivero O, et al.
Translational Psychiatry, 5(10), e655-e655 (2015)
Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations
Org E, et al.
Human Molecular Genetics, 18(12), 2288-2296 (2009)
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