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生物来源
rabbit
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
表单
buffered aqueous solution
分子量
~5 kDa
种属反应性
human
浓度
~1 mg/mL
技术
immunoblotting: 0.25-0.5 μg/mL using human recombinant peptide of MR-Pro ADM (amino acid 45-92)
immunohistochemistry: 20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human pancreas or placenta sections
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ADM(133)
一般描述
MR-pro-ADM (mid-regional-pro-adrenomedullin) is a 47-residue long peptide, produced during posttranslational processing of adrenomedullin. It has a molecular weight of 5.1kDa. Adrenomedullin (ADM) is a vasodilator peptide which is produced and released by a wide variety of cells such as, macrophages, fibroblasts, cardiomyocytes etc. MR-pro-ADM functions as a substitute marker for ADM. This peptide is coded by the gene localized to human chromosome 11p15.4 which is composed of four exons and three introns.
特异性
Anti-MR-Pro ADM (Internal) recognizes human MR-Pro ADM.
免疫原
synthetic peptide corresponding to the internal region of human Adrenomedullin (ADM)
生化/生理作用
In hemodialysis patients increased plasma levels of MR-pro-ADM (mid-regional-pro-adrenomedullin) is linked with decreased survival. This is due to increased vasodilation in response to higher levels of MR-pro-ADM; lower levels of this peptide result in increased vasoconstriction and hence, better prognosis. This peptide is also associated with increased cardiovascular mortality in dialysis patients. In type II diabetic patients, MR-pro-ADM peptide is linked with renal outcome, as adrenomedullin (ADM) gene regualates susceptibility to nephropathic progression.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
储存及稳定性
For continuous use, store at 2–8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Plasma Adrenomedullin and Allelic Variation in the ADM Gene and Kidney Disease in People With Type 2 Diabetes.
Velho G et al
Diabetes, 64(9), 3262-3272 (2015)
N Minamino et al.
Clinical hemorheology and microcirculation, 23(2-4), 95-102 (2001-04-26)
Adrenomedullin (AM) is a vasodilator peptide first identified in pheochromocytoma tissue, but endothelial cells and vascular smooth muscle cells actively secrete AM in addition to expressing AM receptors. AM dilates blood vessels through its direct action on the smooth muscle
Adrenomedullin and tumour microenvironment.
Larrayoz IM et al
Journal of Translational Medicine, 12, 339-339 (2014)
Ferruh Artunc et al.
PloS one, 9(1), e86148-e86148 (2014-01-28)
Vasopressin, endothelin and adrenomedullin are vasoactive peptides that regulate vascular tone and might play a role in hypertensive diseases. Recently, laboratory assays have been developed to measure stable fragments of vasopressin, endothelin and adrenomedullin. Little is known about their diagnostic
Ghazaleh Gouya et al.
PloS one, 6(3), e17803-e17803 (2011-03-17)
High levels of the plasma peptides mid-regional pro-adrenomedullin (MR-proADM) and mid-regional pro-atrial natriuretic peptide (MR-proANP) are associated with clinical outcomes in the general population. Data in patients with chronic kidney disease are sparse. We therefore investigated the association of MR-proANP
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