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生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
H6.10, monoclonal
形式
buffered aqueous solution
分子量
antigen ~14 kDa
种属反应性
chicken, human, monkey, hamster, canine
浓度
~1 mg/mL
技术
immunoblotting: 0.25-0.5 μg/mL using using histones isolated from human HeLa cells.
immunofluorescence: 5-10 μg/mL using using HeLa cells.
同位素/亚型
IgG1
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... HIST1H3A(8350)
一般描述
Histone cluster 1 H3A (HIST1H3A) belongs to the H3 histone family. The gene encoding it is localized on human chromosome 6.
Monoclonal Anti-Histone H3 (C-terminal) (mouse IgG1 isotype) is derived from the hybridoma H6.10 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a sequence at the C terminal region of human Histone H3, conjugated to KLH.
免疫原
a synthetic peptide corresponding to a sequence at the C terminal region of human Histone H3.
应用
Monoclonal Anti-Histone H3 (C-terminal) antibody has been used in
- immunoblotting
- immunofluorescence
- western blotting
生化/生理作用
H3.1 (Histone 3-variant 1) is involved in gene silencing as well as gene activation. Histones H3 and H4 are the predominant histones subjected to extensive covalent modifications. Mutations in histone H3 were identified in various tumors.
Histone cluster 1 H3A (HIST1H3A) has been associated with DNA replication.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Sean M Callahan et al.
Science advances, 9(32), eade2693-eade2693 (2023-08-11)
Histone modifications control numerous processes in eukaryotes, including inflammation. Some bacterial pathogens alter the activity or expression of host-derived factors, including sirtuins, to modify histones and induce responses that promote infection. In this study, we identified a deacetylase encoded by
Expression patterns and post-translational modifications associated with mammalian histone H3 variants
Hake S B, et al.
The Journal of Biological Chemistry, 281(1), 559-568 (2006)
Histone H3. 3 mutations: a variant path to cancer
Yuen B T K and Knoepfler P S
Cancer Cell, 24(5), 567-574 (2013)
Organismal differences in post-translational modifications in histones H3 and H4
Garcia B, et al.
The Journal of Biological Chemistry, 282(10), 7641-7655 (2007)
FERONIA receptor kinase contributes to plant immunity by suppressing jasmonic acid signaling in Arabidopsis thaliana
Guo H, et al
Current Biology, 28(20), 3316-3324 (2018)
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