SAB4200617
Monoclonal Anti-Myb antibody from mouse
clone MB-8, purified immunoglobulin
别名:
Proto-oncogene c-Myb, Transcriptional activator Myb, Transcriptional activator Myb; Proto-oncogene c-Myb
产品名称
Monoclonal Anti-Myb antibody from mouse, clone MB-8, purified immunoglobulin
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
MB-8, monoclonal
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
flow cytometry: 2.5-5 μg/test using using HL-60 cells.
immunoblotting: 0.5-1 μg/mL using using Jurkat total cell extract.
immunofluorescence: 2-4 μg/mL using using HeLa cells.
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MYB(4602)
Application
Monoclonal Anti-Myb antibody from mouse may be used in:
- immunoblotting
- flow cytometry
- immunocytochemistry
Biochem/physiol Actions
MYB is a transcription factor that regulates stem and progenitor cells in the bone marrow, colonic crypts and a neurogenic region of the adult brain. Loss of MYB activity in these cells leads to severe or lethal phenotypes. MYB is an oncogene and is observed in some human leukemias. In addition, It is also observed that MYB is activated in colon and breast cancer.
Monoclonal Anti-Myb recognizes human and mouse Myb.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-Myb (mouse IgG1 isotype) is derived from the hybridoma MB-8 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. MYB proto-oncogene, transcription factor is encoded by the gene mapped to human chromosome 6q23.3.
Immunogen
synthetic peptide corresponding to a sequence at the N-terminal region of human Myb.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For extended storage, freeze at -20 ˚C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
The HBS1L-MYB intergenic region on chromosome 6q23. 3 influences erythrocyte, platelet, and monocyte counts in humans
Menzel S, et al.
Blood, 110(10), 3624-3626 (2007)
MYB function in normal and cancer cells
Ramsay RG, et al.
Nature Reviews. Cancer, 8, 523-534 (2008)
相关内容
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