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生物来源
mouse
质量水平
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
MB-8, monoclonal
种属反应性
human, mouse
浓度
~1 mg/mL
技术
flow cytometry: 2.5-5 μg/test using using HL-60 cells.
immunoblotting: 0.5-1 μg/mL using using Jurkat total cell extract.
immunofluorescence: 2-4 μg/mL using using HeLa cells.
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MYB(4602)
相关类别
一般描述
Monoclonal Anti-Myb (mouse IgG1 isotype) is derived from the hybridoma MB-8 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. MYB proto-oncogene, transcription factor is encoded by the gene mapped to human chromosome 6q23.3.
特异性
Monoclonal Anti-Myb recognizes human and mouse Myb.
免疫原
synthetic peptide corresponding to a sequence at the N-terminal region of human Myb.
应用
Monoclonal Anti-Myb antibody from mouse may be used in:
- immunoblotting
- flow cytometry
- immunocytochemistry
生化/生理作用
MYB is a transcription factor that regulates stem and progenitor cells in the bone marrow, colonic crypts and a neurogenic region of the adult brain. Loss of MYB activity in these cells leads to severe or lethal phenotypes. MYB is an oncogene and is observed in some human leukemias. In addition, It is also observed that MYB is activated in colon and breast cancer.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
储存及稳定性
For extended storage, freeze at -20 ˚C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
The HBS1L-MYB intergenic region on chromosome 6q23. 3 influences erythrocyte, platelet, and monocyte counts in humans
Menzel S, et al.
Blood, 110(10), 3624-3626 (2007)
MYB function in normal and cancer cells
Ramsay RG, et al.
Nature Reviews. Cancer, 8, 523-534 (2008)
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