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SAB4200599

Sigma-Aldrich

Monoclonal Anti-SORBS1 antibody produced in mouse

~1.0 mg/mL, clone SORBS-437, purified immunoglobulin

别名:

Monoclonal Anti-2310065E01RIK, Monoclonal Anti-9530001P15Rik, Monoclonal Anti-CAP, Monoclonal Anti-DKFZp451C066, Monoclonal Anti-DKFZp586P1422, Monoclonal Anti-FLAF2, Monoclonal Anti-FLJ12406, Monoclonal Anti-KIAA1296, Monoclonal Anti-LOC678826, Monoclonal Anti-Ponsin, Monoclonal Anti-R85FL, Monoclonal Anti-RP11-476E15.1, Monoclonal Anti-SH3D5, Monoclonal Anti-SH3P12, Monoclonal Anti-SORB1, Monoclonal Anti-SORBS1, Monoclonal Anti-c-Cbl associated, Monoclonal Anti-mKIAA1296, Monoclonal Anti-sorbin and SH3 domain containing 1

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About This Item

UNSPSC代码:
12352209
NACRES:
NA.41

生物来源

mouse

偶联物

unconjugated

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

SORBS-437, monoclonal

表单

buffered aqueous solution

分子量

antigen ~95 kDa

种属反应性

human, rat, mouse

浓度

~1.0 mg/mL

技术

flow cytometry: 10-20 μg/test using HeLa cells
immunoblotting: 0.25-0.5 μg/mL using Caco-2 total cell extracts

同位素/亚型

IgG1

UniProt登记号

Q9BX66

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... SORBS1(10580)

一般描述

Monoclonal Anti-SORBS1 (mouse IgG1 isotype) is derived from the hybridoma SORBS-437 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. SORBS1 is an adaptor protein and is mainly expressed in insulin-sensitive tissues such as adipose tissue, liver and skeletal muscle.
Sorbin and SH3 domain-containing protein 1 (SORBS1) is also called c-Cbl-associated protein (CAP) or ponsin. The SORBS1 gene is located on human chromosome 10q24.1. SORBS1 has sorbin homology domain (SOHO) and three SH3 (sarcomahomology 3) domains.

特异性

Monoclonal Anti-SORBS1 recognizes human, rat and mouse SORBS1.

免疫原

Synthetic peptide corresponding to an internal sequence of human SORBS1. The isotype is determined by ELISA using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).

应用

Monoclonal Anti-SORBS1 antibody produced in mouse may be used in immunoblotting and flow cytometry.

生化/生理作用

SORBS1 acts as an insulin-signaling molecule by forming a complex with the oncoprotein Cbl.
Sorbin and SH3 domain-containing protein 1 (SORBS1) modulates cell adhesion by interacting with cytoskeletal proteins. It regulates glucose uptake. Polymorphisms in SORBS1 is implicated in obesity, insulin resistance, type 2 diabetes and diabetic nephropathy. It suppresses tumorigenesis by modulating c-Jun N-terminal kinases (JNKs) of mitogen-activated protein kinase (MAPK) signaling pathway in lung and breast cancers.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

储存及稳定性

For extended storage, freeze at -20 0C in working aliquots. Repeated freezing and thawing,or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000157454
0000148883
0000148883
063M4770V

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Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes
Lin WH, et al.
Human Molecular Genetics, 10(17), 1753-1760 (2001)
Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B
Lin WH, et al.
Genomics, 74(1), 12-20 (2001)
SORBS1 suppresses tumor metastasis and improves the sensitivity of cancer to chemotherapy drug
Song L, et al.
Oncotarget, 8(6), 9108-9108 (2017)
Wei-Shiung Yang et al.
Obesity research, 11(4), 586-590 (2003-04-12)
The SORBS1 gene has been shown to be an important adaptor protein in the insulin-signaling pathway in many molecular and cellular biology studies. However, its roles in humans either in health or disease are rarely explored. In this report, we
CAP defines a second signalling pathway required for insulin-stimulated glucose transport
Baumann C, et al.
Nature, 407(6801), 202-202 (2000)
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