SAB4200599
Monoclonal Anti-SORBS1 antibody produced in mouse
~1.0 mg/mL, clone SORBS-437, purified immunoglobulin
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别名:
Monoclonal Anti-2310065E01RIK, Monoclonal Anti-9530001P15Rik, Monoclonal Anti-CAP, Monoclonal Anti-DKFZp451C066, Monoclonal Anti-DKFZp586P1422, Monoclonal Anti-FLAF2, Monoclonal Anti-FLJ12406, Monoclonal Anti-KIAA1296, Monoclonal Anti-LOC678826, Monoclonal Anti-Ponsin, Monoclonal Anti-R85FL, Monoclonal Anti-RP11-476E15.1, Monoclonal Anti-SH3D5, Monoclonal Anti-SH3P12, Monoclonal Anti-SORB1, Monoclonal Anti-SORBS1, Monoclonal Anti-c-Cbl associated, Monoclonal Anti-mKIAA1296, Monoclonal Anti-sorbin and SH3 domain containing 1
UNSPSC代码:
12352209
NACRES:
NA.41
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生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
SORBS-437, monoclonal
形式
buffered aqueous solution
分子量
antigen ~95 kDa
种属反应性
human, rat, mouse
浓度
~1.0 mg/mL
技术
flow cytometry: 10-20 μg/test using HeLa cells
immunoblotting: 0.25-0.5 μg/mL using Caco-2 total cell extracts
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SORBS1(10580)
一般描述
Monoclonal Anti-SORBS1 (mouse IgG1 isotype) is derived from the hybridoma SORBS-437 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. SORBS1 is an adaptor protein and is mainly expressed in insulin-sensitive tissues such as adipose tissue, liver and skeletal muscle.
Sorbin and SH3 domain-containing protein 1 (SORBS1) is also called c-Cbl-associated protein (CAP) or ponsin. The SORBS1 gene is located on human chromosome 10q24.1. SORBS1 has sorbin homology domain (SOHO) and three SH3 (sarcomahomology 3) domains.
特异性
Monoclonal Anti-SORBS1 recognizes human, rat and mouse SORBS1.
免疫原
Synthetic peptide corresponding to an internal sequence of human SORBS1. The isotype is determined by ELISA using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).
应用
Monoclonal Anti-SORBS1 antibody produced in mouse may be used in immunoblotting and flow cytometry.
生化/生理作用
SORBS1 acts as an insulin-signaling molecule by forming a complex with the oncoprotein Cbl.
Sorbin and SH3 domain-containing protein 1 (SORBS1) modulates cell adhesion by interacting with cytoskeletal proteins. It regulates glucose uptake. Polymorphisms in SORBS1 is implicated in obesity, insulin resistance, type 2 diabetes and diabetic nephropathy. It suppresses tumorigenesis by modulating c-Jun N-terminal kinases (JNKs) of mitogen-activated protein kinase (MAPK) signaling pathway in lung and breast cancers.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
储存及稳定性
For extended storage, freeze at -20 0C in working aliquots. Repeated freezing and thawing,or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
CAP defines a second signalling pathway required for insulin-stimulated glucose transport
Baumann C, et al.
Nature, 407(6801), 202-202 (2000)
Wei-Shiung Yang et al.
Obesity research, 11(4), 586-590 (2003-04-12)
The SORBS1 gene has been shown to be an important adaptor protein in the insulin-signaling pathway in many molecular and cellular biology studies. However, its roles in humans either in health or disease are rarely explored. In this report, we
SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes
Germain M, et al.
Diabetologia, 58(3), 543-548 (2015)
Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes
Lin WH, et al.
Human Molecular Genetics, 10(17), 1753-1760 (2001)
Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B
Lin WH, et al.
Genomics, 74(1), 12-20 (2001)
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