SAB4200594
Anti-APC (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-Adenomatous polyposis coli protein, Anti-BTPS2, Anti-DP2, Anti-DP2.5, Anti-DP3, Anti-FAP, Anti-GS
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunoblotting
immunohistochemistry
indirect immunofluorescence
immunohistochemistry
indirect immunofluorescence
Species reactivity:
human
Citations:
4
Technique(s):
immunoblotting: 3-6 μg/mL using lysates of HeLa or SW620 cells.
immunohistochemistry: 10-20 μg/mL using formalin-fixed, paraffin-embedded human colon or duodenum.
indirect immunofluorescence: 2-4 μg/mL using Caco-2 cells.
immunohistochemistry: 10-20 μg/mL using formalin-fixed, paraffin-embedded human colon or duodenum.
indirect immunofluorescence: 2-4 μg/mL using Caco-2 cells.
Uniprot accession no.:
产品名称
Anti-APC (C-terminal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~300 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoblotting: 3-6 μg/mL using lysates of HeLa or SW620 cells.
immunohistochemistry: 10-20 μg/mL using formalin-fixed, paraffin-embedded human colon or duodenum.
indirect immunofluorescence: 2-4 μg/mL using Caco-2 cells.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... APC(324)
Application
Anti-APC (C-terminal) antibody produced in rabbit has been used in:
- immunoblotting
- immunofluorescence
- immunohistochemistry
Biochem/physiol Actions
Adenomatous Polyposis Coli (APC) has a key role in the proteasome-mediated degradation of β-catenin. APC mutations cause accumulation of β-catenin in the nucleus leading to activation of LEF-1 and/or TCF, and the induction of target genes such as the oncogene c-myc. It is involved in regulation of mitotic chromosome separation and stability.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Adenomatous Polyposis Coli (APC) is a tumor suppressor gene. The APC gene encodes a large multifunctional protein that has critical functions in cell migration, adhesion and proliferation. It is a shuttling nucleo-cytoplasmic protein expressed in various tissues and its expression in the colorectal epithelium contributes to its normal growth and differentiation.
Immunogen
synthetic peptide corresponding to a sequence at the C-terminal region of human APC, conjugated to KLH. The corresponding sequence is identical in human APC isoform b and highly conserved (single amino acid substitution) in rat and mouse APC.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
APC shuttling to the membrane, nucleus and beyond
Brocardo M and Henderson BR
Trends in Cell Biology, 18(12), 587-596 (2008)
APC, signal transduction and genetic instability in colorectal cancer
Fodde R, et al.
Nature Reviews. Cancer, 1(1), 55-55 (2001)
Adenomatous polyposis coli (APC): a multi-functional tumor suppressor gene
Aoki K and Taketo MM
Journal of Cell Science, 120(19), 3327-3335 (2007)
Teng Sun et al.
Oncotarget, 8(1), 444-457 (2016-11-24)
The molecular biological mechanisms underlying the evolutionary biologic changes leading to carcinogenesis remain unclear. The main objective of our study was to explore the evolution of the microbiota community and molecules related with CRC in the dynamic transition from normal
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