SAB4200585
Anti-ERGIC-53 antibody, Mouse monoclonal
clone ERGIC-3, purified from hybridoma cell culture
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别名:
Monoclonal Anti-ER-Golgi intermediate compartment 53 kDa protein, Monoclonal Anti-ERGIC-53 antibody produced in mouse, Monoclonal Anti-ERGIC53, Monoclonal Anti-F5F8D, Monoclonal Anti-Gp58, Monoclonal Anti-Intracellular mannose-specific lectin MR60, Monoclonal Anti-LMAN1, Monoclonal Anti-Lectin mannose-binding 1
UNSPSC代码:
12352203
NACRES:
NA.41
推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
ERGIC-3, monoclonal
形式
buffered aqueous solution
分子量
antigen ~58 kDa
种属反应性
mouse, human, rat
浓度
~1 mg/mL
技术
immunoblotting: 1-2 μg/mL using whole extracts of human HeLa cells.
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... LMAN1(3998)
mouse ... Lman1(70361)
rat ... Lman1(116666)
一般描述
Endoplasmic reticulum-Golgi intermediate compartment 53kDa protein (ERGIC-53), a nonglycosylated, hexameric type I integral membrane protein is also known as LMAN1 (lectin, mannose-binding 1). This gene is located on human chromosome 18q21.32.
免疫原
synthetic peptide corresponding to an internal sequence of human ERGIC-53, conjugated to KLH. The corresponding sequence is identical in mouse, rat, bovine and monkey.
生化/生理作用
Endoplasmic reticulum-Golgi intermediate compartment protein 53kDa protein (ERGIC-53) plays an important role in the proliferation of arenavirus, coronavirus and filovirus. This intracellular cargo receptor enables the anterograde passage of very few glycoprotein ligands in the early exocytic pathway. Mutations in ERGIC-53 (LMAN1) gene results in the deficiency of factor V and factor VIII.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Two new mutations at ERGIC-53 gene in a Turkish family
Torun, et al.
Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 17(3), 248-250 (2011)
Dependence on electron transport chain function and intracellular signaling of genomic responses in SH-SY5Y cells to the mitochondrial neurotoxin MPP+
Brill L B II, et al.
Experimental Neurology, 181(1), 25-38 (2003)
Morihisa Fujita et al.
The Journal of cell biology, 194(1), 61-75 (2011-07-06)
Glycosylphosphatidylinositol (GPI) anchoring of proteins is a posttranslational modification occurring in the endoplasmic reticulum (ER). After GPI attachment, proteins are transported by coat protein complex II (COPII)-coated vesicles from the ER. Because GPI-anchored proteins (GPI-APs) are localized in the lumen
The intracellular cargo receptor ERGIC-53 is required for the production of infectious arenavirus, coronavirus, and filovirus particles
Klaus JP, et al.
Cell host & microbe, 14(5), 522-534 (2013)
Mariana L Ferrari et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(27), 13582-13591 (2019-06-19)
Intracellular trafficking pathways in eukaryotic cells are essential to maintain organelle identity and structure, and to regulate cell communication with its environment. Shigella flexneri invades and subverts the human colonic epithelium by the injection of virulence factors through a type
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