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Merck
CN

SAB4200576

抗-COX2 兔抗

~1.0 mg/mL, affinity isolated antibody

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NACRES:
NA.41
UNSPSC Code:
12352203

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产品名称

抗-COX2 兔抗, ~1.0 mg/mL, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~75 kDa

species reactivity

human, mouse

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

concentration

~1.0 mg/mL

technique(s)

indirect immunofluorescence: 5-10 μg/mL using RAW-264.7 cells stimulated with LPS
western blot: 1.5-3.0 μg/mL using lysates of RAW-264.7 cells stimulated with LPS, and of HEK-293T cells overexpressing human COX2

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... COX2(5743)

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相关类别

Application

Anti-COX2 antibody produced in rabbit has been used in immunohistochemical staining.

Biochem/physiol Actions

Cyclooxygenase (COX) catalyzes the conversion of arachidonic acid (AA) to prostaglandins (PG). Mutation in the gene is associated with the development of gastric cancer. Elevated expression of the gene has been observed in various chronic and autoimmune diseases.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Cytochrome c oxidase subunit II (COX2) is encoded by the gene mapped to human chromosome 1. The encoded protein is one of the isoforms of COX protein. It is expressed in specific cells such as activated macrophages, monocytes, neutrophils and lymphocytes, in response to inflammatory stimuli such as mitogen, cytokines and growth factors.

Immunogen

synthetic peptide corresponding to an internal sequence of human COX2 (GeneID: 5743), conjugated to KLH. The corresponding sequence has high homology to rat COX2 (83% identity) and to mouse COX2 (82% identity).

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000132588
0000094430
098M4865V
077M4869V
033M4752V

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Detection and Clinical Significance of COX-2 Gene SNPs in Gastric Cancer.
Lu X, et al.
Cell Biochemistry and Biophysics, 72(3), 657-660 (2015)
Expression of IL-17 and COX2 gene in peripheral blood leukocytes of vitiligo patients.
Esmaeili B, et al.
Iranian Journal of Allergy, Asthma, and Immunology, 10(2), 81-81 (2011)
Immunohistological study of the effect of extravirgin olive oil on aspartame-treated cerebellum of male albino rat
Baky F A F A .
Menoufia Medical Journal, 29(3), 728-728 (2016)
Daisuke Yokokawa et al.
Experimental and therapeutic medicine, 27(2), 75-75 (2024-01-24)
Cluster of differentiation (CD)44 is a marker of dental pulp stem cells and is involved in odontoblast differentiation and calcification. Chemokine-like receptor 1 (CMKLR1), also known as chemerin receptor 23 (ChemR23) is also expressed in odontoblasts and dental pulp stem
Emilie Mathieu et al.
Chemical communications (Cambridge, England), 56(57), 7885-7888 (2020-06-11)
A conjugate of a Mn-based superoxide dismutase mimic with a Re-based multimodal probe 1[combining low line] was studied in a cellular model of oxidative stress. Its speciation was investigated using Re and Mn X-fluorescence. Interestingly, 1[combining low line] shows a
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Data Sheet - SAB4200576

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