生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen ~75 kDa
种属反应性
human, mouse
增强验证
recombinant expression
Learn more about Antibody Enhanced Validation
浓度
~1.0 mg/mL
技术
indirect immunofluorescence: 5-10 μg/mL using RAW-264.7 cells stimulated with LPS
western blot: 1.5-3.0 μg/mL using lysates of RAW-264.7 cells stimulated with LPS, and of HEK-293T cells overexpressing human COX2
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... COX2(5743)
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相关类别
一般描述
Cytochrome c oxidase subunit II (COX2) is encoded by the gene mapped to human chromosome 1. The encoded protein is one of the isoforms of COX protein. It is expressed in specific cells such as activated macrophages, monocytes, neutrophils and lymphocytes, in response to inflammatory stimuli such as mitogen, cytokines and growth factors.
免疫原
synthetic peptide corresponding to an internal sequence of human COX2 (GeneID: 5743), conjugated to KLH. The corresponding sequence has high homology to rat COX2 (83% identity) and to mouse COX2 (82% identity).
应用
Anti-COX2 antibody produced in rabbit has been used in immunohistochemical staining.
生化/生理作用
Cyclooxygenase (COX) catalyzes the conversion of arachidonic acid (AA) to prostaglandins (PG). Mutation in the gene is associated with the development of gastric cancer. Elevated expression of the gene has been observed in various chronic and autoimmune diseases.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Daisuke Yokokawa et al.
Experimental and therapeutic medicine, 27(2), 75-75 (2024-01-24)
Cluster of differentiation (CD)44 is a marker of dental pulp stem cells and is involved in odontoblast differentiation and calcification. Chemokine-like receptor 1 (CMKLR1), also known as chemerin receptor 23 (ChemR23) is also expressed in odontoblasts and dental pulp stem
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Baky F A F A .
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Expression of IL-17 and COX2 gene in peripheral blood leukocytes of vitiligo patients.
Esmaeili B, et al.
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Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2024-07-31)
This observational study investigated the regulatory mechanism of Pim-1 in inflammatory signaling pathways. THP-1, RAW 264.7, BV2, and Jurkat human T cell lines were used. None. Lipopolysaccharide (LPS) was used to induce inflammation, followed by PIM1 knockdown. Western blot, immunoprecipitation
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A conjugate of a Mn-based superoxide dismutase mimic with a Re-based multimodal probe 1[combining low line] was studied in a cellular model of oxidative stress. Its speciation was investigated using Re and Mn X-fluorescence. Interestingly, 1[combining low line] shows a
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