Anti-MST1R antibody produced in rabbit

Macrophage-stimulating protein receptor (MST1R) is a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. It is a heterodimer of disulfide-linked α- and β-subunits, generated by proteolytic cleavage of a single-chain precursor. MST1R is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung. It belongs to the MET receptor tyrosine kinase family. MST1R is located on the human chromosome at 3p21.31.

Anti-MST1R recognizes human MST1R.

synthetic peptide corresponding to an internal region of human MST1R, conjugated to KLH. The corresponding sequence is identical in rat and differs by 2 amino acids in mouse.

Anti-MST1R antibody produced in rabbit may be used in immunoblotting.

Macrophage-stimulating protein receptor (MST1R) takes part in tumorigenesis. MST1R along with MSP is involved in host defense. Mutation of MST1R is associated with carcinoma of the breast, bladder, lung, colon, prostate, ovary and pancreas. Increased levels of MST1R is observed in aggressive tumors with poor patient survival.

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

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