SAB4200529
Anti-HMGCR (internal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-3-hydroxy-3-methylglutaryl-CoA reductase, LDLCQ3
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
human, mouse, rat
Citations:
9
Technique(s):
western blot: 1.5-3.0 μg/mL using extracts of mevastatin-treated HepG2 cells, and of mouse and rat liver microsomes.
Uniprot accession no.:
产品名称
Anti-HMGCR (internal) antibody produced in rabbit, ~1.0 mg/mL, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~100 kDa
species reactivity
human, mouse, rat
concentration
~1.0 mg/mL
technique(s)
western blot: 1.5-3.0 μg/mL using extracts of mevastatin-treated HepG2 cells, and of mouse and rat liver microsomes.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HMGCR(3156)
Biochem/physiol Actions
3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) plays a major role in mevalonate biosynthesis, which is a rate limiting step of cholesterol biosynthesis in the liver. Additionally, it also plays a key role in various biological process such as, embryogenesis and cancer. Elevated expression of the gene is associated with the development of gastric cancer(GC) and glioblastoma cells. Thus, HMGCR can be considered as a potent therapeutic target for GC and glioblastoma.
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) acts as the rate-limiting step in cholesterol synthesis. Polymorphism in HMGCR results in late-onset Alzheimer′s disease. It induces the growth and migration of the cancer cells.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is a transmembrane glycoprotein, encoded by the gene mapped to human chromosome 5q13.3-q14. HMGCR has a molecular mass of 97kDa and is mainly localized to smooth endoplasmic reticulum. The encoded protein is predominantly expressed in liver tissues.
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) codes for a part of the statin-binding domain of the enzyme. This gene is located on human chromosome 5q13. HMGCR has a molecular mass of 97kDa and is mainly localized to smooth endoplasmic reticulum. The encoded protein is predominantly expressed in liver tissues.
Immunogen
synthetic peptide corresponding to an internal sequence of human HMGCR, conjugated to KLH. The corresponding sequence is identical in human HMGCR isoform 2 and highly conserved in mouse (89% identity) and in rat (83% identity) HMGCR.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Genes for HMG-CoA reductase and serotonin 1a receptor are on mouse chromosome 13
Sundaresan S
Somatic Cell and Molecular Genetics, 15, 465-469 (1989)
Hmgcr in the Corpus Allatum Controls Sexual Dimorphism of Locomotor Activity and Body Size via the Insulin Pathway in Drosophila
Belgacem YH and Martin JR
PLoS ONE, 2 (2007)
HMGCR positively regulated the growth and migration of glioblastoma cells.
Qiu Z
Gene, 576, 22-27 (2016)
HMGCR is up-regulated in gastric cancer and promotes the growth and migration of the cancer cells.
Chushi L
Gene, 587, 42-47 (2016)
Xiaojia Chen et al.
Heliyon, 9(12), e22785-e22785 (2023-12-13)
Methyl protodioscin (MPD) is the main component of total diosgenin, which was reported to reduce cholesterol and triglyceride levels potentially. This study aimed to investigate the beneficial effects of MPD against lipid disorder in hyperlipidemic gerbils induced by a high-fat
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