生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen ~55-70 kDa
种属反应性
mouse, rat, human
浓度
~1.0 mg/mL
技术
western blot: 0.5-1.0 μg/mL using rat spinal cord extracts (S1 fraction)
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SLC2A1(6513)
mouse ... Slc2a1(20525)
rat ... Slc2a1(24778)
一般描述
Glucose transporter 1 (GLUT1, SLC2A1) belongs to the family of glucose transporters (GLUTs). It is localized to the membrane and is highly expressed in the brain and spinal cord, with a relative high density in the cerebellum. The vascular form of GLUT1 is mainly localized in endothelial cells of blood vessels.
免疫原
peptide corresponding to a sequence at the C-terminus of human GLUT1, conjugated to KLH. The corresponding sequence is identical in rat and mouse GLUT1.
应用
Anti-GLUT1 (C-terminal) antibody produced in rabbit has been used in immunoblotting.
生化/生理作用
GLUT1 is the main glucose transporter in the blood-brain barrier (BBB), which regulates basal glucose levels. Increased expression of GLUT1 is associated with cell growth and in malignant transformation.
外形
solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Glucose transporters: expression, regulation and cancer
Medina RA and Owen GI
Biological Research, 35(1), 9-26 (2002)
Aarón Guerrero et al.
Frontiers in cardiovascular medicine, 8, 644797-644797 (2021-06-29)
Diabetes mellitus (DM) causes high glucose (HG) levels in the plasma and urine. The (pro)renin receptor (PRR) is a key regulator of renal Na+ handling. PRR is expressed in intercalated (IC) cells of the collecting duct (CD) and binds renin
Immunohistochemical localization and quantification of glucose transporters in the mouse brain
Choeiri C, et al.
Neuroscience, 111(1), 19-34 (2002)
Differential localization of glucose transporter isoforms in non-polarized mammalian cells: distribution of GLUT1 but not GLUT3 to detergent-resistant membrane domains
Sakyo T and Kitagawa T
Biochimica et Biophysica Acta - Biomembranes, 1567, 165-175 (2002)
Photobiomodulatory effects of superpulsed 904 nm laser therapy on bioenergetics status in burn wound healing
Yadav A, et al.
Journal of Photochemistry and Photobiology. B, Biology, 162, 77-85 (2016)
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