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Merck
CN

SAB4200515

Sigma-Aldrich

抗 弧 兔抗

enhanced validation

~1.0 mg/mL, affinity isolated antibody

别名:

Anti-Activity-regulated cytoskeleton-associated protein, Anti-Arc3.1, Anti-Arg3.1

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen ~55 kDa

种属反应性

rat, mouse, human

增强验证

recombinant expression
Learn more about Antibody Enhanced Validation

浓度

~1.0 mg/mL

技术

immunohistochemistry: 20 μg/mL using formalin-fixed, paraffin-embedded rat brain
western blot: 1.5-3 μg/mL using U937 cell extracts

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... ARC(23237)
mouse ... Arc(11838)
rat ... Arc(54323)

一般描述

Activity regulated cytoskeleton associated protein (Arc) is encoded by the gene mapped to human chromosome 8q24.3.

免疫原

synthetic peptide corresponding to a sequence at the C-terminal region of human Arc, conjugated to KLH. The corresponding sequence is identical in rat and mouse Arc.

生化/生理作用

Activity regulated cytoskeleton associated protein (Arc) plays a vital role in memory formation. It also facilitates activity-dependent plasticity of dendrites. Mutation in the gene has been associated with the development of idiopathic generalized epilepsy (IGE).

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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Mutation screening of the chromosome 8q24.3-human activity-regulated cytoskeleton-associated gene (ARC) in idiopathic generalized epilepsy.
Haug K
Molecular and Cellular Probes, 14, 255-260 (2000)
Joseph Phan et al.
Scientific reports, 10(1), 13611-13611 (2020-08-14)
The two hypothalamic neuropeptides oxytocin and melanin concentrating hormone (MCH) share several physiological actions such as the control of maternal care, sexual behavior, and emotions. In this study, we uncover the role for the oxytocin-MCH signaling pathway in mood regulation.
Insulin-induced expression of the activity-regulated cytoskeleton-associated gene (ARC) in human neuroblastoma cells requires p21ras, mitogen-activated protein kinase/extracellular regulated kinase and src tyrosine kinases but is protein kinase C-independent
Kremerskothen J
Neuroscience Letters, 321, 153-156 (2002)
G L Lyford et al.
Neuron, 14(2), 433-445 (1995-02-01)
Neuronal activity is an essential stimulus for induction of plasticity and normal development of the CNS. We have used differential cloning techniques to identify a novel immediate-early gene (IEG) cDNA that is rapidly induced in neurons by activity in models

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