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安全信息

SAB4200465

Sigma-Aldrich

Anti-Kindlin-1 antibody, Mouse monoclonal

clone KN-4, purified from hybridoma cell culture

别名:

Monoclonal Anti-C20orf42, Monoclonal Anti-DTGCU2, Monoclonal Anti-FERMT1 URP1, Monoclonal Anti-KIND1, Monoclonal Anti-Kindlin-1 antibody produced in mouse, Monoclonal Anti-UNC112A, Monoclonal Anti-fermitin family member 1

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

mouse

质量水平

200

偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

抗体产品类型

primary antibodies

克隆

KN-4, monoclonal

表单

buffered aqueous solution

分子量

antigen ~50 kDa (isoform 4)
antigen ~60 kDa (isoform 2)
antigen ~77 kDa (isoform 1)

种属反应性

mouse, human

浓度

~1.0 mg/mL

技术

indirect immunofluorescence: 2.5-5.0 μg/mL using SW-620 cells
western blot: 1.0-2.0 μg/mL using SW-48 total cell extracts

同位素/亚型

IgG1

UniProt登记号

Q9BQL6

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... FERMT1(55612)
mouse ... Fermt1(241639)

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一般描述

Kindlin-1 is coded by FERMT1 (fermitin family member 1) gene. It is a focal adhesion protein, expressed in the skin and intestine. FERMT1 is located on human chromosome 20p.12.3.

免疫原

synthetic peptide corresponding to a sequence close to the N-terminus of human Kindlin-1, conjugated to KLH. The isotype is determined by ELISA using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).

应用

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Monoclonal Anti-Kindlin-1 antibody has been used in immunohistochemistry, immunofluorescence staining and western blotting.

生化/生理作用

Kindlin-1 protein, coded by FERMT1 gene modulates keratinocyte electrotaxis. It participates in the initiation of the integrin family of extracellular matrix receptors. FERMT1 maintains the lamellipodial protrusions at the time of electrotaxis. Mutations in kindlin-1 results in Kindler syndrome (KS).

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
0000364758
0000364758
0000386134
0000199570
0000181175

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Case of Kindler syndrome resulting from mutation in the FERMT1 gene
Wada MM, et al.
The Journal of Dermatology, 39(12), 1057-1058 (2012)
Kindlin-2 controls TGF-beta signalling and Sox9 expression to regulate chondrogenesis
Wu CJ, et al.
Nature Communications, 6(4), 7531-7531 (2015)
Kindlin-1 contributes to EGF-induced re-epithelialization in skin wound healing
Shen CS, et al.
International Journal of Molecular Medicine, 39(4), 949-959 (2017)
Congcong Shen et al.
International journal of molecular medicine, 39(4), 949-959 (2017-03-16)
The commercial use of epidermal growth factor (EGF) is extensive and has been shown to be effective for skin wound healing in clinical practice. There is evidence to indicate that the topical administration of EGF significantly accelerates re-epithelialization by promoting keratinocyte
Kindlin-1 regulates keratinocyte electrotaxis
Zhang G G, et al.
The Journal of Investigative Dermatology, 136(11), 2229-2239 (2016)
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