Anti-FUS (internal) antibody produced in rabbit

Fused in sarcoma (FUS) is a RNA/DNA binding protein mapped to human chromosome 16p11.2. Although FUS is located predominantly in the nucleus, pathological FUS inclusions are mostly found in the cytosol of neurons and glial cells.

Anti-FUS (internal) specifically recognizes human and rat FUS.

synthetic peptide corresponding to an internal region of human FUS isoform 1, conjugated to KLH. The corresponding sequence is identical in human FUS isoforms 2 and 3, and in mouse and rat FUS.

Anti-FUS (internal) antibody produced in rabbit has been used in:

• immunoblotting
• immunofluorescence
• immunohistochemistry

Fused in sarcoma (FUS) plays regulatory roles in transcription, RNA splicing and transport and is implicated in multiple diseases. Chromosomal translocation of FUS/TLS is found in human cancers and results in the production of oncogenic FUS fusion proteins. Recently, FUS has been implicated in a broadening spectrum of neurodegenerative disorders. FUS has been identified as a component of inclusion bodies in patients with Huntington′s disease (HD) and spinocerebellar ataxias (SCA1-3). More recently, mutations in TDP-43 and FUS have been identified in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FLTD) including ubiquitin-positive inclusions (FLTD-U). The majority of the FUS mutations have been identified in C-terminal nuclear localization signal (NLS).

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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