SAB4200452
Anti-ADFP / PLIN2 antibody, Mouse monoclonal
clone ADFP-5, purified from hybridoma cell culture
别名:
Adipophilin, Plin2 Antibody, Plin2 Antibody - Monoclonal Anti-ADFP / PLIN2 antibody produced in mouse, Anti-ADRP, Anti-Perilipin 2, Monoclonal Anti-ADFP / PLIN2 antibody produced in mouse
产品名称
Anti-ADFP / PLIN2 antibody, Mouse monoclonal, clone ADFP-5, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
ADFP-5, monoclonal
form
buffered aqueous solution
mol wt
antigen ~48 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 5-10 μg/mL using human HepG2 or SH-SY5Y cells
western blot: 2-4 μg/mL using whole extracts of HEK-293T cells overexpressing human ADFP
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PLIN2(123)
Application
Monoclonal Anti-ADFP / PLIN2 antibody produced in mouse may be used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
Monoclonal Anti-ADFP/PLIN2 recognizes human ADFP/PLIN2.
PLIN2 may serve as a biomarker of lipid accumulation in diverse cell types and diseases.
Perilipin 2 (PLIN2) plays a vital role in uptake and storage of lipids as triacylglycerols in lipid droplets in skeletal muscle. PLIN2 is also involved in the regulation of lipid metabolism. High levels of PLIN2 is beneficial for the prevention of insulin resistance. Overexpression of PLIN2 is associated with clear cell renal cell carcinoma (CC-RCC).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Monoclonal Anti-ADFP/PLIN2 (mouse IgG1 isotype) is derived from the hybridoma ADFP-5 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide.
Perilipin 2 (PLIN2) is a 50 kDa major protein belonging to perilipin family. It is present on lipid droplets found in the cytoplasm of variety of cells as hepatocytes, adipocytes, muscle cells, mammary epithelial cells, fibroblasts, endothelial cells and macrophages. PLIN2 gene, spanning 14 kb, with eight exons, is located on human chromosome 9p22.1.
Immunogen
a synthetic peptide corresponding to a sequence at the C-terminus of human PLIN2, conjugated to KLH.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8°C for up to one month. For extended storage, freeze at -20oC in working aliquots. Repeated freezing and thawing,or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Preferential utilization of perilipin 2-associated intramuscular triglycerides during 1 h of moderate-intensity endurance-type exercise
Shepherd SO, et al.
Experimental Physiology, 97(8), 970-980 (2012)
Olivier Sorg et al.
JID innovations : skin science from molecules to population health, 1(4), 100057-100057 (2021-12-16)
In adipocytes and sebocytes, lipid droplet proteins control the storage of lipids in organized droplets and their release on demand. The contribution of lipid droplet proteins to the pathogenesis of acne is plausible because they control the levels of comedogenic
H W Heid et al.
Cell and tissue research, 294(2), 309-321 (1998-11-03)
We report the human DNA and protein sequence of adipophilin and its association with the surface of lipid droplets. The amino acid sequence of human adipophilin has been determined by using cDNA clones from several tissues and confirmed by the
Structure of the gene encoding mouse adipose differentiation-related protein (ADRP)
Eisinger DP and Serrero G
Genomics, 16(3), 638-644 (1993)
Adipophilin as prognostic biomarker in clear cell renal cell carcinoma
Tolkach Y, et al.
Testing, 8(17), 28672-28672 (2017)
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