SAB4200452
Anti-ADFP / PLIN2 antibody, Mouse monoclonal
clone ADFP-5, purified from hybridoma cell culture
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所有图片(3)
别名:
Adipophilin, Plin2 Antibody, Plin2 Antibody - Monoclonal Anti-ADFP / PLIN2 antibody produced in mouse, Anti-ADRP, Anti-Perilipin 2, Monoclonal Anti-ADFP / PLIN2 antibody produced in mouse
UNSPSC代码:
12352203
NACRES:
NA.41
推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
ADFP-5, monoclonal
形式
buffered aqueous solution
分子量
antigen ~48 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
indirect immunofluorescence: 5-10 μg/mL using human HepG2 or SH-SY5Y cells
western blot: 2-4 μg/mL using whole extracts of HEK-293T cells overexpressing human ADFP
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PLIN2(123)
一般描述
Monoclonal Anti-ADFP/PLIN2 (mouse IgG1 isotype) is derived from the hybridoma ADFP-5 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide.
Perilipin 2 (PLIN2) is a 50 kDa major protein belonging to perilipin family. It is present on lipid droplets found in the cytoplasm of variety of cells as hepatocytes, adipocytes, muscle cells, mammary epithelial cells, fibroblasts, endothelial cells and macrophages. PLIN2 gene, spanning 14 kb, with eight exons, is located on human chromosome 9p22.1.
特异性
Monoclonal Anti-ADFP/PLIN2 recognizes human ADFP/PLIN2.
免疫原
a synthetic peptide corresponding to a sequence at the C-terminus of human PLIN2, conjugated to KLH.
应用
Monoclonal Anti-ADFP / PLIN2 antibody produced in mouse may be used in immunoblotting and immunofluorescence.
生化/生理作用
PLIN2 may serve as a biomarker of lipid accumulation in diverse cell types and diseases.
Perilipin 2 (PLIN2) plays a vital role in uptake and storage of lipids as triacylglycerols in lipid droplets in skeletal muscle. PLIN2 is also involved in the regulation of lipid metabolism. High levels of PLIN2 is beneficial for the prevention of insulin resistance. Overexpression of PLIN2 is associated with clear cell renal cell carcinoma (CC-RCC).
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
储存及稳定性
For continuous use, store at 2-8°C for up to one month. For extended storage, freeze at -20oC in working aliquots. Repeated freezing and thawing,or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of beta-oxidation
Larigauderie G, et al.
FEBS Journal, 273(15), 3498-3510 (2006)
Identification and validation of a 44-gene expression signature for the classification of renal cell carcinomas
Wang Q, et al.
Journal of Experimental & Clinical Cancer Research, 36(1), 176-176 (2017)
Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels
Bosma M, et al.
Diabetes, DB_111402-DB_111402 (2012)
Overexpression of PLIN2 is a prognostic marker and attenuates tumor progression in clear cell renal cell carcinoma
Cao Q, et al.
International Journal of Oncology, 53(1), 137-147 (2018)
Maria Conte et al.
PloS one, 8(8), e73709-e73709 (2013-08-27)
Human aging is associated with a progressive loss of muscle mass and strength and a concomitant fat accumulation in form of inter-muscular adipose tissue, causing skeletal muscle function decline and immobilization. Fat accumulation can also occur as intra-muscular triglycerides (IMTG)
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