推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~58 kDa
种属反应性
human, rat, mouse
浓度
~1.0 mg/mL
技术
indirect immunofluorescence: 2.5-5 μg/mL using human HeLa cells.
western blot: 2.5-5.0 μg/mL using whole extracts of HEK-293T cells over-expressing mouse NMD3.
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NMD3(51068)
mouse ... Nmd3(97112)
rat ... Nmd3(310512)
一般描述
NMD3 ribosome export adaptor (NMD3) is an adaptor for 60S subunit export via the export receptor CRM1 (XPO1). In human, the C-terminal domain of NMD3 comprises a CRM1- dependent leucine-rich nuclear export signal (NES) and a nuclear localization signal (NLS) in its. Two zinc-binding centres and the ribosome-binding domain forms the N-terminal domain.
免疫原
peptide corresponding to an internal region of human NMD3, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey, bovine and dog.
应用
Anti-NMD3 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
生化/生理作用
NMD3 ribosome export adaptor (NMD3) is a highly conserved nucleocytoplasmic shuttling protein, essential for nuclear export of 60S ribosomal subunits.
外形
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates
Trotta CR, et al.
The Embo Journal, 22(11), 2841-2851 (2003)
Characterization of the nuclear export adaptor protein Nmd3 in association with the 60S ribosomal subunit
Sengupta J, et al.
The Journal of Cell Biology, 189(7), 1079-1086 (2010)
Baoyan Bai et al.
Nucleus (Austin, Tex.), 4(4), 315-325 (2013-06-21)
CRM1 is an export factor that together with its adaptor NMD3 transports numerous cargo molecules from the nucleus to cytoplasm through the nuclear pore. Previous studies have suggested that CRM1 and NMD3 are detected in the nucleolus. However, their localization
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