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安全信息

SAB4200451

Sigma-Aldrich

Anti-NMD3 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

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别名:
Anti-60S Ribosomal export protein NMD3, Anti-CGI-07, Anti-NMD3 homolog (S. cerevisiae)
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

200

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

分子量

antigen ~58 kDa

种属反应性

human, rat, mouse

浓度

~1.0 mg/mL

技术

indirect immunofluorescence: 2.5-5 μg/mL using human HeLa cells.
western blot: 2.5-5.0 μg/mL using whole extracts of HEK-293T cells over-expressing mouse NMD3.

UniProt登记号

Q96D46

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... NMD3(51068)
mouse ... Nmd3(97112)
rat ... Nmd3(310512)

一般描述

NMD3 ribosome export adaptor (NMD3) is an adaptor for 60S subunit export via the export receptor CRM1 (XPO1). In human, the C-terminal domain of NMD3 comprises a CRM1- dependent leucine-rich nuclear export signal (NES) and a nuclear localization signal (NLS) in its. Two zinc-binding centres and the ribosome-binding domain forms the N-terminal domain.

免疫原

peptide corresponding to an internal region of human NMD3, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey, bovine and dog.

应用

Anti-NMD3 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

生化/生理作用

NMD3 ribosome export adaptor (NMD3) is a highly conserved nucleocytoplasmic shuttling protein, essential for nuclear export of 60S ribosomal subunits.

外形

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates
Trotta CR, et al.
The Embo Journal, 22(11), 2841-2851 (2003)
Characterization of the nuclear export adaptor protein Nmd3 in association with the 60S ribosomal subunit
Sengupta J, et al.
The Journal of Cell Biology, 189(7), 1079-1086 (2010)
Baoyan Bai et al.
Nucleus (Austin, Tex.), 4(4), 315-325 (2013-06-21)
CRM1 is an export factor that together with its adaptor NMD3 transports numerous cargo molecules from the nucleus to cytoplasm through the nuclear pore. Previous studies have suggested that CRM1 and NMD3 are detected in the nucleolus. However, their localization

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