推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
rat, human
技术
immunohistochemistry: 1:100-1:200 using formalin-fixed paraffin-embedded rat brain and cerebellum.
indirect immunofluorescence: 1:100-1:200 using human HeLa cells.
western blot: 1:4000-1:8000 using whole extracts of HEK-293T cells overexpressing human recombinant SOX11
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SOX11(6664)
一般描述
Sex determining region Y (SRY)-box 11 (SOX11) protein belongs to the SRY-related high mobility group (HMG)-box (SOX) family of transcription factors. This protein is localized in adult immature neurons but is normally not expressed in any other adult tissue. SOX11 gene is located on the human chromosome 2p25.2.
特异性
Anti-SOX11 (C-terminal) recognizes human and rat SOX11.
免疫原
peptide corresponding to the C-terminal region of human SOX11, conjugated to KLH. The corresponding sequence is identical in monkey, bovine and pig and differs by a single amino acid in mouse and rat.
应用
Anti-SOX11 (C-terminal) antibody produced in rabbit may be used in:
- immunoblotting
- immunofluorescence
- immunohistochemistry
生化/生理作用
Sex determining region Y (SRY)-box 11 (SOX11) plays a role in the regulation of tissue remodeling during embryogenesis which is essential for neurogenesis. This protein is also involved in tumorigenesis. SOX11 protein also plays a role in the determination of cell fate. Upregulation of the SOX11 gene leads to ovarian cancer, brain tumor, medulloblastomas and gliomas. This protein functions as a biomarker in mantle cell lymphoma (MCL), acute lymphoblastic leukemia (ALL) and Burkitt lymphomas (BL).
外形
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
储存及稳定性
For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Esther Palomino Lago et al.
Animals : an open access journal from MDPI, 14(1) (2024-01-11)
Fractures caused by bone overloading are a leading cause of euthanasia in Thoroughbred racehorses. The risk of fatal fracture has been shown to be influenced by both environmental and genetic factors but, to date, no specific genetic mechanisms underpinning fractures
Maria Carmela Vegliante et al.
PloS one, 6(6), e21382-e21382 (2011-07-09)
Recent studies have shown aberrant expression of SOX11 in various types of aggressive B-cell neoplasms. To elucidate the molecular mechanisms leading to such deregulation, we performed a comprehensive SOX11 gene expression and epigenetic study in stem cells, normal hematopoietic cells
Xiao Wang et al.
PloS one, 5(11), e14085-e14085 (2010-12-03)
The SRY (sex determining region Y)-box 11 (SOX11) gene, located on chromosome 2p25, encodes for a transcription factor that is involved in tissue remodeling during embryogenesis and is crucial for neurogenesis. The role for SOX11 in hematopoiesis has not yet
Lakshmi Pillai-Kastoori et al.
PLoS genetics, 10(7), e1004491-e1004491 (2014-07-11)
Ocular coloboma is a sight-threatening malformation caused by failure of the choroid fissure to close during morphogenesis of the eye, and is frequently associated with additional anomalies, including microphthalmia and cataracts. Although Hedgehog signaling is known to play a critical
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