SAB4200424
Anti-COG1 (C-TERMINAL) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-CDG2G, Anti-COG complex subunit 1, Anti-LDLB, Anti-component of oligomeric golgi complex 1, Anti-conserved oligomeric Golgi complex subunit 1, Anti-low density lipoprotein receptor defect
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所有图片(5)
About This Item
UNSPSC代码:
12352203
NACRES:
NA.41
推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~110 kDa
种属反应性
mouse, human, rat
浓度
~1.0 mg/mL
技术
indirect immunofluorescence: 1-2 μg/mL using human HeLa cells.
western blot: 2.5-5.0 μg/mL using whole extracts of mouse LA-4 cells.
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... COG1(9382)
mouse ... Cog1(16834)
rat ... Cog1(303652)
一般描述
COG1 is a member of the conserved oligomeric Golgi (COG) complex. COG complex is an evolutionarily conserved multi-subunit protein complex. COG complex consists of eight distinct subunits organized in two heterotrimeric groups, Cog2-Cog3-Cog4 and Cog5-Cog6-Cog7, which are linked by the dimeric group formed by Cog1 and Cog8.
Conserved oligomeric Golgi (COG) subunit 1 is an essential component of the conserved oligomeric Golgi complex. It is encoded by the gene mapped to human chromosome 17q25.1.
免疫原
peptide corresponding to the C-terminal region of human COG1, conjugated to KLH. The corresponding sequence is identical in mouse, rat and monkey COG1.
应用
Anti-COG1 (C-TERMINAL) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
生化/生理作用
COG1 is required for steps in the normal medial and trans Golgi-associated processing of glycoconjugates. It plays a role in the organization of the Golgi-localized complex. Mutations in COG1 in humans cause novel types of congenital disorders of glycosylation (CDG). COG complex regulates membrane trafficking and maintenance of Golgi glycosylation machinery in eukaryotic cells.
Conserved oligomeric Golgi (COG) complex plays a vital role in retrograde vesicular trafficking and glycosylation.
外形
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Cerebrocostomandibular-like syndrome and a mutation in the conserved oligomeric Golgi complex, subunit 1.
Zeevaert R
Human Molecular Genetics, 18, 517-524 (2009)
Conserved oligomeric Golgi complex specifically regulates the maintenance of Golgi glycosylation machinery
Pokrovskaya ID, et al.
Glycobiology, 21(12), 1554-1569 (2011)
Genome-wide Examination of Chromosomal Aberrations
in Neuroblastoma SH-SY5Y Cells by Array-based Comparative
Genomic Hybridization
Do JH
Molecules and Cells, 24, 105-112 (2007)
Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation
Smith RD and Lupashin VV
Carbohydrate Research, 343(12), 2024-2031 (2008)
Comparative analyses of the Conserved Oligomeric Golgi (COG) complex in vertebrates
Quental R, et al.
BMC Evolutionary Biology, 10(1), 212-212 (2010)
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