推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
TN-17, monoclonal
表单
buffered aqueous solution
分子量
antigen ~170 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
indirect immunofluorescence: 2.5-5.0 μg/mL using PC3 cells.
western blot: 0.5-1.0 μg/mL using extracts of SW-620 cells.
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... TNS3(64759)
一般描述
Monoclonal Anti-Tensin 3 (mouse IgG1 isotype) is derived from the hybridoma TN-17 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to an internal sequence of human Tensin 3. Tensins are multidomain proteins that are characterized with homologous C1, protein phosphatases (PTPases) , C2, Src homology 2 (SH2) domains and pTyr-binding (PTB) domains.
Tensin 3 (TNS3) is encoded by the gene mapped to human chromosome 7p12.3. TNS3 transcript is expressed at high level in thyroid and at moderate level in placenta. In addition, the protein is also expressed at minimal levels in brain, heart, lung, liver, pancreas, kidney, skeletal muscle, white blood cells and prostate. TNS3 is a member of tensin protein family.
免疫原
synthetic peptide corresponding to an internal sequence of human Tensin 3, conjugated to KLH. The isotype is determined using a double diffusion immunoassay using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).
应用
Monoclonal Anti-Tensin 3 antibody produced in mouse has also been used in immunofluorescence.
Monoclonal Anti-Tensin 3 antibody produced in mouse has been used in western blotting.
生化/生理作用
Tensin 3 (TNS3) plays a vital role in stimulation of epidermal growth factor (EGF) signaling pathway. The encoded protein supports fundamental role of thyroid hormone in normal thyroid tissues. Decreased expression of the gene leads to development of human renal cell carcinoma (RCC).
Tensin 3 facilitates cell migration and tumorigenesis in cell lines from advanced lung cancer, breast cancer and melanoma. In these cell lines, The protein is phosphorylated by Src in its SH2 domain, leading to tumorigenesis and metastasis, implicating tensin 3 as an oncoprotein regulated by Src.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
CpG dinucleotide-specific hypermethylation of the TNS3 gene promoter in human renal cell carcinoma
Carter JA
Epigenetics, 8, 739-747 (2013)
Musashi-1 Enhances Glioblastoma Cell Migration and Cytoskeletal Dynamics through Translational Inhibition of Tensin3
Chen HY
Scientific Reports, 7, 8710-8710 (2017)
Increased expression levels of tensin3 mRNA in thyroid functional adenomas as compared to non-functioning adenomas.
Maeda I
Experimental and Clinical Endocrinology & Diabetes, 117, 191-193 (2009)
Tensin3 is a novel thyroid-specific gene
Maeda I
Journal of Molecular Endocrinology, 36, R1-R8 (2008)
Epidermal Growth Factor Modulates Tyrosine Phosphorylation of a Novel Tensin Family Member, Tensin311Supported in part by the Shriners Hospitals Research Award and NIH CA102537.
Cui Y
Molecular Cancer Research (2004)
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