SAB4200412
单克隆抗 PLAUR/uPAR 小鼠抗
clone PL231, purified from hybridoma cell culture
别名:
Anti-CD87, Anti-Plasminogen activator urokinase receptor, Anti-UPAR, Anti-URKR, Monoclonal Anti-PLAUR/uPAR antibody produced in mouse
产品名称
单克隆抗 PLAUR/uPAR 小鼠抗, clone PL231, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
PL231, monoclonal
form
buffered aqueous solution
mol wt
antigen ~55 kDa
species reactivity
monkey, rat, canine, human, mouse
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: suitable
western blot: 4.0-8.0 μg/mL using extracts of HL-60 cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PLAUR(5329)
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Application
Monoclonal Anti-PLAUR/uPAR antibody produced in mouse has been used in Western blotting (WB).
Biochem/physiol Actions
Plasminogen activator, urokinase receptor (PLAUR) plays a vital role in tumor cell invasion, angiogenesis and metastasis. It acts as a key regulator of cell-surface plasminogen activator. It is implicated in various normal and pathological processes. Elevated expression of the gene has been observed in various types of cancers, including head and neck squamous cell carcinoma (HNSCC). Thus, it is considered as an potent biomarker for targeted imaging or therapy. Upregulated expression of PLAUR leads to the progression of kidney disease in children.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Plasminogen activator, urokinase receptor (PLAUR) is a well-characterized receptor for matrix-degrading proteases. It is encoded by the gene mapped to human chromosome 19q13.31.
Immunogen
peptide corresponding to a sequence at the C-terminus of human PLAUR/uPAR.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer.
Harris N L E, et al.
Oncogene, 36(30), 4288-4288 (2017)
Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds.
Chang H Y, et al.
PLoS Biology, 2(2), 7-7 (2004)
John H Rossmeisl et al.
OncoTargets and therapy, 10, 2077-2085 (2017-04-27)
The expression of the urokinase plasminogen activator receptor (uPAR), a glycosylphosphatidylinositol-anchored protein family member, and the activity of its ligand, urokinase-type plasminogen activator (uPA), have been associated with the invasive and metastatic potentials of a variety of human brain tumors
Association of Serum Soluble Urokinase Receptor Levels With Progression of Kidney Disease in Children.
Schaefer F, et al.
JAMA Pediatrics, 171(11), e172914-e172914 (2017)
Assignment of the Urokinase-Type Plasminogen Activator Receptor Gene (PLAUR) to Chromosome 1 9q 13.1 -q 13.2
B?rglum A D, et al.
American Journal of Human Genetics, 50(3), 492-492 (1992)
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