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安全信息

SAB4200403

Sigma-Aldrich

Anti-EXOSC8 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

别名:

Anit-CIP3, Anit-Exosome component 8,p9, Anti-EAP2, Anti-OIP2, Anti-Opa interacting protein 2, Anti-RP11-421P11.3, Anti-RRP43, Anti-Ribosomal RNA-processing protein 43, Anti-Rrp43p, AntiCBP-interacting protein 3

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

200

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen ~34 kDa

种属反应性

mouse, human, rat

浓度

~1.0 mg/mL

技术

immunoprecipitation (IP): 1-2 μg using human HEK-293T cell lysate
western blot: 1-2 μg/mL using whole extracts of mouse A20 and rat PC12 cells

UniProt登记号

Q96B26

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

bovine ... EXOSC8(532080)
dog ... EXOSC8(477300)
human ... EXOSC8(11340)
mouse ... Exosc8(69639)

一般描述

Exosome component 8 (EXOSC8) or RRP43, a 3′ to 5′ exoribonuclease, is a component of the eukaryotic exosome (a 400 kDa complex). EXOSC8 is part of the hexameric ring, along with EXOSC4-7 and EXOSC9. This is further capped by three RNA binding subunits (EXOSC1-EXOSC3). EXOSC8 gene is mapped to human chromosome 13q13.3 and is localized in nucleus and cytoplasm.

特异性

Anti-EXOSC8 (N-terminal) recognizes human, mouse and rat EXOSC8.

免疫原

peptide corresponding to the N-terminal region of human EXOSC8, conjugated to KLH.

应用

Anti-EXOSC8 (N-terminal) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.

生化/生理作用

Exosome component 8 (EXOSC8) interacts with AU-rich element (ARE)-containing mRNAs and its deficiency halts growth in yeast. Mutations in the EXOSC8 gene is implicated in Ponto-cerebellar hypoplasia.

外形

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

储存及稳定性

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
121M4770

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Pontocerebellar hypoplasia with rhombencephalosynapsis and microlissencephaly expands the spectrum of PCH type 1B
Saugier-Veber P, et al.
European Journal of Medical Genetics, 63(4), 103814-103814 (2020)
Identification of the phytosphingosine metabolic pathway leading to odd-numbered fatty acids
Kondo N, et al.
Nature Communications, 5(1), 1-13 (2014)

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