生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen ~60 kDa
种属反应性
mouse, human, rat
浓度
~1.0 mg/mL
技术
immunoprecipitation (IP): 5-10 μg using lysates of HEK-293T cells over-expressing human SMAD6.
indirect immunofluorescence: 10-20 μg/mL using mouse 3T3 cells.
western blot: 0.5-1.0 μg/mL using whole extracts of HEK-293T cells over-expressing human SMAD6.
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SMAD6(4091)
mouse ... Smad6(17130)
rat ... Smad6(374096)
一般描述
SMAD family member 6 (SMAD6) is encoded by the gene mapped to human chromosome 15q22.31. The encoded protein is localized in both nuclei and cytoplasm and is expressed in variety of human tissues, including ovary. SMAD6 consists of MAD homology 2 (MH2) domain, involved in protein-protein interaction.
免疫原
peptide corresponding to the C-terminal region of human SMAD6, conjugated to KLH. The corresponding sequence is identical in rat, mouse and bovine.
生化/生理作用
SMAD family member 6 (SMAD6) induces endocytosis and negatively regulates apoptosis by inhibiting transforming growth factor-β (TGF-β) signaling pathway. In addition, it also indirectly regulates stemness by inhibiting erythropoiesis in cord blood hematopoietic stem cells (HSCs). Mutation in the gene leads to congenital cardiovascular malformation (CVM). Overexpression or genetic variation of SMAD6 is associated with the development of ovarian cancer.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Genetic variants in TGF-β pathway are associated with ovarian cancer risk.
Yin J, et al.
PLoS ONE, 6(9), e25559-e25559 (2011)
Statistical genetic analysis of serological measures of common, chronic infections in Alaska Native participants in the GOCADAN study.
Rubicz R
Genetic Epidemiology, 37(7), 751-757 (2013)
Inhibition of erythropoiesis by Smad6 in human cord blood hematopoietic stem cells.
Kang YJ
Biochemical and Biophysical Research Communications, 423(4), 750-756 (2012)
Nonsynonymous variants in the SMAD6 gene predispose to congenital cardiovascular malformation.
Tan HL
Human Mutation, 33(4), 720-727 (2012)
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