SAB4200343
Anti-MLL2 antibody, Mouse monoclonal
clone MLL2-A, purified from hybridoma cell culture
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别名:
Monoclonal Anti-MLL2 antibody produced in mouse, Anti-AAD10, Anti-ALL1-related protein, Anti-ALR, Anti-CAGL114, Anti-Histone-lysine N-methyltransferase, Anti-KMS, Anti-KMT2B, Anti-KMT2D, Anti-Kabuki make-up syndrome, Anti-Kabuki mental retardation syndrome, Anti-MLL4, Anti-Myeloid/lymphoid or mixed-lineage leukemia 2, Anti-TNRC21
UNSPSC代码:
12352203
NACRES:
NA.41
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生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
MLL2-A, monoclonal
形式
buffered aqueous solution
分子量
antigen ~17 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
indirect immunofluorescence: suitable
western blot: 0.2-0.5 μg/mL using using human MLL2 partial fusion protein (immunogen)
同位素/亚型
IgG1
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MLL2(8085)
一般描述
Myeloid/lymphoid or mixed-lineage leukemia 2 (MLL2) belongs to the SET family of proteins. The SET domain of MLL2 confers strong histone 3 lysine 4 methyltransferase activity. MLL2 is part of a large protein complex called activating signal cointegrator-2 complex (ASCOM).
免疫原
Fusion protein corresponding to the C-terminus of human MLL2. The corresponding sequence is identical in mouse and rat MLL2 and shares 85% homology with MLL3.
应用
Monoclonal Anti-MLL2 antibody produced in mouse has been used in immunoblotting and immunofluorescence.
生化/生理作用
MLL2 acts as an epigenetic transcriptional activator during growth and development. It functions as a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene are linked to Kabuki syndrome.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome
Ng SB, et al.
Nature Genetics, 42(9), 790-790 (2010)
PLK1 signaling in breast cancer cells cooperates with estrogen receptor-dependent gene transcription
Wierer M, et al.
Cell Reports, 3(6), 2021-2032 (2013)
ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity
Kim DH, et al.
Molecular Endocrinology, 23(10), 1556-1562 (2009)
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