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安全信息

SAB4200343

Sigma-Aldrich

Anti-MLL2 antibody, Mouse monoclonal

clone MLL2-A, purified from hybridoma cell culture

别名:

Monoclonal Anti-MLL2 antibody produced in mouse, Anti-AAD10, Anti-ALL1-related protein, Anti-ALR, Anti-CAGL114, Anti-Histone-lysine N-methyltransferase, Anti-KMS, Anti-KMT2B, Anti-KMT2D, Anti-Kabuki make-up syndrome, Anti-Kabuki mental retardation syndrome, Anti-MLL4, Anti-Myeloid/lymphoid or mixed-lineage leukemia 2, Anti-TNRC21

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

mouse

质量水平

200

偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

抗体产品类型

primary antibodies

克隆

MLL2-A, monoclonal

表单

buffered aqueous solution

分子量

antigen ~17 kDa

种属反应性

human

浓度

~1.0 mg/mL

技术

indirect immunofluorescence: suitable
western blot: 0.2-0.5 μg/mL using using human MLL2 partial fusion protein (immunogen)

同位素/亚型

IgG1

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... MLL2(8085)

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一般描述

Myeloid/lymphoid or mixed-lineage leukemia 2 (MLL2) belongs to the SET family of proteins. The SET domain of MLL2 confers strong histone 3 lysine 4 methyltransferase activity. MLL2 is part of a large protein complex called activating signal cointegrator-2 complex (ASCOM).

免疫原

Fusion protein corresponding to the C-terminus of human MLL2. The corresponding sequence is identical in mouse and rat MLL2 and shares 85% homology with MLL3.

应用

Monoclonal Anti-MLL2 antibody produced in mouse has been used in immunoblotting and immunofluorescence.

生化/生理作用

MLL2 acts as an epigenetic transcriptional activator during growth and development. It functions as a transcriptional regulator of the beta-globin and estrogen receptor genes. Mutations in this gene are linked to Kabuki syndrome.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
029M4812V
061M4882

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PLK1 signaling in breast cancer cells cooperates with estrogen receptor-dependent gene transcription
Wierer M, et al.
Cell Reports, 3(6), 2021-2032 (2013)
ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity
Kim DH, et al.
Molecular Endocrinology, 23(10), 1556-1562 (2009)
Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome
Ng SB, et al.
Nature Genetics, 42(9), 790-790 (2010)

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