生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen ~190 kDa (Rat)
antigen ~200 kDa (Human)
种属反应性
human, rat, mouse
浓度
~1.5 mg/mL
技术
immunoprecipitation (IP): 5-10 μg using extracts of HEK-293T cells overexpressing human LRP1B.
indirect immunofluorescence: 1-2 μg/mL using HEK-293T cells overexpressing human LRP1B.
western blot: 1.5-3.0 μg/mL using extracts of rat brain (S1 fraction) and mouse brain (S1 fraction).
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... LRP1B(53353)
mouse ... Lrp1b(94217)
rat ... Lrp1b(311926)
一般描述
LDL receptor-related protein 1B (LRP1B) belongs to the low-density lipoprotein (LDL) receptor gene family, including LDLR, LRPs (low density lipoprotein related proteins), megalin/GP330, VLDLR (very low density lipoprotein receptor) and ApoER2.
免疫原
synthetic peptide corresponding to a sequence near the C-terminus of human LRP1B, conjugated to KLH. The corresponding sequence is identical in mouse LRP1B.
应用
Anti-LRP1B (C-terminal region) antibody produced in rabbit has been used in:
- immunoblotting
- immunoprecipitation
- immunofluorescence
生化/生理作用
LDL receptor-related protein 1B (LRP1B) is a candidate tumor suppressor gene, that is inactivated in several types of human malignancies, including non-small cell lung cancer (NSCLC) and plays an important role in tumorigenesis. It regulates the endocytic trafficking of the β-amyloid precursor protein (APP) and reduces the production of amyloid-β peptide (Ab) involved in the pathogenesis of Alzheimer′s disease. LRP1B regulates the degradation of the platelet derived growth factor-β receptor (PDGFR-β) and is implicated in the development of atherosclerosis.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production
Cam JA, et al.
The Journal of Biological Chemistry, 279(28), 29639-29646 (2004)
gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells
Liu CX, et al.
The Journal of Biological Chemistry, 282(10), 7504-7511 (2007)
Joana Peixoto et al.
International journal of molecular sciences, 24(14) (2023-07-29)
LRP1B remains one of the most altered genes in cancer, although its relevance in cancer biology is still unclear. Recent advances in gene editing techniques, particularly CRISPR/Cas9 systems, offer new opportunities to evaluate the function of large genes, such as
Can-Hui Cao et al.
International journal of biological sciences, 17(7), 1744-1756 (2021-05-18)
Human papillomavirus (HPV) infection and gene mutations were reputed as key factors in cervical carcinoma (CC) and head and neck squamous cell carcinoma (HNSCC). However, the associations of HPV status and gene mutations remain to be determined. This study aims
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
Bu G
Nature Reviews. Neuroscience, 10(5), 333-333 (2009)
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