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安全信息

SAB4200267

Sigma-Aldrich

Anti-O-GlcNAcase (OGA) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody

别名:

Anti-Beta-N-acetylhexosaminidase, Anti-Hexosaminidase C, Anti-MEA5, Anti-Meningioma expressed antigen 5 (hyaluronidase), Anti-N-acetyl-beta-D-glucosaminidase, Anti-N-acetyl-beta-glucosaminidase, Anti-NCOAT

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About This Item

UNSPSC代码:
12352203

生物来源

rabbit

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

形式

buffered aqueous solution

分子量

antigen ~130 kDa

种属反应性

human, mouse, canine

浓度

~1.5 mg/mL

技术

indirect immunofluorescence: 5-10 μg/mL using A431 cells
western blot: 1.5-3.0 μg/mL using MDCK and mouse kidney extracts.

UniProt登记号

O60502

运输

dry ice

储存温度

−20°C

基因信息

human ... MGEA5(10724)
mouse ... Mgea5(76055)
rat ... Mgea5(154968)

免疫原

synthetic peptide corresponding to a sequence located near the N-terminus of human O-GlcNAcase (OGA), conjugated to KLH. The corresponding sequence is identical in human OGA isoform B, and in rat and mouse OGA.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

分析证书(COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the immunogen sequence used to develop antibody SAB4200267, Anti-O-GlcNAcase (OGA) antibody produced in rabbit?

    The immunogen sequence used to develop antibody SAB4200267, Anti-O-GlcNAcase (OGA) antibody produced in rabbit, is: TYLYAPKDDYKHRMFWRE. 

  6. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Fuxing Zhou et al.
Theranostics, 8(19), 5200-5212 (2018-12-18)
Cisplatin resistance significantly affects the survival rate of patients with ovarian cancer. However, the main mechanism underlying cisplatin resistance in ovarian cancer remains unclear. Methods: Immunohistochemistry was used to determine the expression of OGT, OGA and O-GlcNAc in chemoresistant and
Villo Muha et al.
The Journal of biological chemistry, 295(26), 8636-8646 (2020-02-26)
O-GlcNAcylation is an abundant post-translational modification in neurons. In mice, an increase in O-GlcNAcylation leads to defects in hippocampal synaptic plasticity and learning. O-GlcNAcylation is established by two opposing enzymes: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). To investigate the role
Sung-Kyun Park et al.
Cell reports, 20(5), 1088-1099 (2017-08-03)
Modification of nucleocytoplasmic proteins with O-GlcNAc regulates a wide variety of cellular processes and has been linked to human diseases. The enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) add and remove O-GlcNAc, but the mechanisms regulating their expression remain unclear.
Yuntian Shen et al.
Journal of the American Heart Association, 7(17), e009634-e009634 (2018-10-30)
Background The mechanisms underlying worse outcome at advanced age after cardiac arrest ( CA ) and resuscitation are not well understood. Because protein homeostasis (proteostasis) is essential for cellular and organismal health, but is impaired after CA , we investigated
Kristin Halvorsen Hortemo et al.
Physiological reports, 3(2) (2015-02-26)
Myosin light chain 2 (MLC2) is a small protein in the myosin complex, regulating muscle contractile function by modulating Ca(2+) sensitivity of myofilaments. MLC2 can be modified by phosphorylation and O-GlcNAcylation, two reversible and dynamic posttranslational modifications. The slow isoform
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