SAB4200266
Anti-PP2A, C subunit antibody, Mouse monoclonal
clone 7A6, purified from hybridoma cell culture
别名:
MonoclonalAnti-PP2Ac, MonoclonalAnti-PP2CA, MonoclonalAnti-PP2Calpha, MonoclonalAnti-PPP2CA, MonoclonalAnti-RP-C, MonoclonalAnti-protein phosphatase 2, catalytic subunit, alpha isozyme
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所有图片(3)
About This Item
UNSPSC代码:
12352203
NACRES:
NA.44
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
7A6, monoclonal
形式
buffered aqueous solution
分子量
antigen 36 kDa
种属反应性
human, mouse, rat
浓度
~1.0 mg/mL
技术
immunoprecipitation (IP): suitable
western blot: 1-2 μg/mL using whole extracts of mouse 3T3, rat Rat2 or human A431 cells.
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PPP2CA(5515)
mouse ... Ppp2ca(19052)
rat ... Ppp2ca(24672)
一般描述
PP2A is a serine/threonine phosphatase that downregulates the MAP kinase pathway and subsequently modulates mitogenic signaling. This phosphatase also mediates localization of Sgo1 at centromeres, Ras-1 activation, and chromosome segregation. The catalytic subunit of PP2A (PP2Ac) regulates the signaling pathway for glucose-stiμLated insulin secretion .
特异性
Monoclonal Anti-PP2Ac is specific for the α and β isoforms of PP2Ac in humans, rats and mice. The antibody has not been tested in other species for cross-reactivity.
应用
MonoclonalAnti-PP2A, C subunit antibody produced in mouse has been used in immunoblotting and immunoprecipitation.
生化/生理作用
Protein phosphatase 2A (PP2A) is implicated in the negative control of cell growth and division. PP2Ac undergoes two post-translational modifications, phosphorylation and methylation, which are involved in the regulation of the enzyme activity.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
Janssens V and Goris J
The Biochemical Journal, 353(3), 417-439 (2001)
Giridhar R Jangati et al.
Endocrine, 31(3), 248-253 (2007-10-02)
Among various phosphatases, the protein phosphatase 2A (PP2A) is relatively well studied in the islet. Previously, we have demonstrated that the catalytic subunit of PP2A (PP2Ac) undergoes okadaic acid (OKA)-sensitive, reversible carboxylmethylation (CML), which appears to be requisite for glucose-stimulated
PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit.
Hegarat N, Vesely C, Vinod PK, et al.
PLoS Genetics, 10(1), e1004004-e1004004 (2014)
Nadia Hégarat et al.
PLoS genetics, 10(1), e1004004-e1004004 (2014-01-07)
Entry into mitosis is triggered by activation of Cdk1 and inactivation of its counteracting phosphatase PP2A/B55. Greatwall kinase inactivates PP2A/B55 via its substrates Ensa and ARPP19. Both Greatwall and Ensa/ARPP19 are regulated by phosphorylation, but the dynamic regulation of Greatwall
Donghai Liu et al.
Nature communications, 12(1), 2551-2551 (2021-05-07)
Endogenous cardiac pacemaker function regulates the rate and rhythm of cardiac contraction. The mutation p.Lys23Glu in the cohesin protein Shugoshin-1 causes severe heart arrhythmias due to sinoatrial node dysfunction and a debilitating gastrointestinal motility disorder, collectively termed the Chronic Atrial
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