SAB4200241
Anti-PP2A subunit B isoform PR55-α antibody, Mouse monoclonal
clone 2G9, purified from hybridoma cell culture
别名:
Anti-B55α, Anti-PPP2R2A, Anti-PR52A, Anti-PR55A, Anti-Protein phosphatase 2 (formerly 2A), regulatory subunit B (PR52), alpha isoform, Anti-Protein phosphatase 2, regulatory subunit B, alpha, B55A, Anti-Serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, alpha isoform
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所有图片(3)
About This Item
UNSPSC代码:
12352203
NACRES:
NA.44
生物来源
mouse
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
2G9, monoclonal
形式
buffered aqueous solution
分子量
antigen 50-55 kDa
种属反应性
rat, human, mouse
浓度
~1.0 mg/mL
技术
immunohistochemistry: suitable
indirect immunofluorescence: suitable
western blot: 1-2 μg/mL using whole extracts of mouse 3T3, rat NRK or human HeLa cells
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PPP2R2A(5520)
mouse ... Ppp2r2a(71978)
rat ... Ppp2r2a(117104)
一般描述
Monoclonal Anti-PP2A subunit B isoform PR55- (mouse IgG1 isotype) is derived from the hybridoma 2G9 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of rat PP2A subunit B isoform PR55-. PP2A subunit B isoform PR55- (PPP2R2A) belongs to the phosphatase (PP)2A regulatory subunit B family. Protein phosphatase 2A is one of the major Ser/Thr phosphatases. PPP2R2A encodes an alpha isoform of the regulatory subunit B55 subfamily. This gene is mapped to human chromosome 8p21.2.
特异性
Monoclonal Anti- PP2A subunit B isoform PR55-α binds to rat, human and mouse PP2A subunit B isoform PR55-α. The antibody may also react with rat PP2A-B55-δ, human PP2A-B55-β and weakly associates with rabbit PP2A-B55-γ.
应用
Monoclonal Anti-PP2A subunit B isoform PR55-α antibody produced in mouse has been used in:
- immunoblotting
- immunohistochemistry
- immunofluorescence
生化/生理作用
PP2A is a serine/threonine phosphatase that downregulates the MAP kinase pathway and subsequently modulates mitogenic signaling. This phosphatase also mediates cellular invasion, localization of Sgo1 at centromeres, cell movement, Ras-1 activation, and chromosome segregation. PP2A protein complex consists of a dimeric core containing subunits A and C; which in turn associates with the regulatory subunit B. PP2A subunit B is involved in the degranulation of mast cells . Monoclonal Anti- PP2A subunit B isoform PR55-α binds to rat, human and mouse PP2A subunit B isoform PR55-α. The antibody may also react with rat PP2A-B55-δ, human PP2A-B55-β and weakly associates with rabbit PP2A-B55-γ.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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