推荐产品
生物来源
mouse
偶联物
unconjugated
抗体形式
tissue culture supernatant
抗体产品类型
primary antibodies
克隆
CAV1, monoclonal
表单
buffered aqueous solution
分子量
antigen 22 kDa
种属反应性
rat, human, mouse
增强验证
independent
Learn more about Antibody Enhanced Validation
技术
immunohistochemistry: suitable
indirect immunofluorescence: 1:1000-1:2000 using human HUVEC or mouse 3T3 cells.
western blot: suitable
同位素/亚型
IgM
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CAV1(857)
mouse ... Cav1(12389)
rat ... Cav1(25404)
一般描述
小窝蛋白-1（CAV1）是一种多功能支架蛋白，具有三个外显子。它定位于人类染色体7q31。
免疫原
合成肽，对应于人小窝蛋白-1 N 末端的序列，与 KLH 偶联。
生化/生理作用
小窝蛋白-1可能在癌症的生长和演化中发挥重要作用。它参与葡萄糖代谢。它也可能参与血管生成。Cav-1有助于控制葡萄糖转运蛋白的表达。
外形
含有 15 mM 叠氮化钠的培养上清液。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Ye Xiong et al.
Oncotarget, 8(15), 24902-24914 (2017-02-18)
As the most prevalent primary brain tumor, gliomas are highly metastatic, invasive and are characteristic of high levels of glial cell-line derived neurotrophic factor (GDNF). GDNF is an important factor for invasive glioma cell growth; however, the underlying mechanism involved
Margaret E Tome et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 38(12), 2209-2222 (2018-10-23)
P-glycoprotein (PgP) is the major drug efflux pump in human cerebral microvessels. PgP prevents pathogens, toxins and therapeutic drugs from entering the CNS. Understanding the molecular regulation of PgP activity will suggest novel mechanisms to improve CNS drug delivery. Previously
Estrogen insensitivity in a model of estrogen receptor positive breast cancer lymph node metastasis.
Joshua Chuck Harrell et al.
Cancer research, 67(21), 10582-10591 (2007-11-03)
The lymphatic system is a common avenue for the spread of breast cancer cells and dissemination through it occurs at least as frequently as hematogenous metastasis. Approximately 75% of primary breast cancers are estrogen receptor (ER) positive and the majority
Claudia Matthaeus et al.
PloS one, 14(10), e0223620-e0223620 (2019-10-11)
Endothelial nitric oxide synthase (eNOS)-related vessel relaxation is a highly coordinated process that regulates blood flow and pressure and is dependent on caveolae. Here, we investigated the role of caveolar plasma membrane stabilization by the dynamin-related ATPase EHD2 on eNOS-nitric
Adam C Midgley et al.
The Journal of biological chemistry, 290(18), 11218-11234 (2015-02-27)
Hyaluronan (HA) promotes transforming growth factor (TGF)-β1-driven myofibroblast phenotype. However, HA can also have disease-limiting activity. Bone morphogenetic protein-7 (BMP7) is an antifibrotic cytokine that antagonizes TGF-β1, and isolated studies have demonstrated that HA can both mediate and modulate BMP7
商品
Quantitative and qualitative western blotting to validate knockdown by esiRNA.
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